C-C chemokine receptor type 5

BE0000911ProteinHumansCCR5

Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. It is acted on by 19 drugs in DrugBank.

Gene name
CCR5
UniProtKB entry
P51681Swiss-Prot
Cellular location
Cell membrane
Residues / weight
352 residues · 40,524 Da
Also known as
C-C CKR-5 · CC-CKR-5 · CCR-5 · CCR5 · CHEMR13

Resolves to

Protein
UniProtP51681UniProt nameCCR5_HUMAN
Gene
HGNCHGNC:1606NCBI Gene1234GenBank1262811GeneCardsCCR5
Pharmacology
IUPHAR/GtoPdb62KEGGhsa:1234
Structure
PDB2L87PDB2MZXPDB2RLL
Drugs

What you can answer from here — as of September 07, 2019

19DrugsApproved to experimental, with action, bond type and pharmacological action
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15Clinical trialsTrials of drugs acting on it, by phase and status
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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93+ReferencesStructured and connected to the statements they support
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Which approved drugs act on C-C chemokine receptor type 5, how selective are they, and which programs against it are still in active trials?

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