INCB-9471

DB12960InvestigationalSmall molecule

INCB-9471 is a novel, orally available CCR5 antagonist that is part of a new class of drugs to treat HIV/AIDS. It is a potent, selective inhibitor of the HIV-1 virus.

Mechanism: INCB-9471 is an antagonist of CCR5. It works through a different mechanism of action than currently marketed oral antiviral drugs. Rather than fighting HIV inside a patient's white blood cells, it prevents the virus from entering uninfected cells by blocking its predominant entry route, the CCR5 co-receptor.
Curator reviewed
Formula / weight: C₃₀H₄₀F₃N₅O₂ · 559.678 g/mol (avg)
Code names: INCB-009471 · INCB9471

Resolves to

Compound

UNIIC5D4W25708CAS869769-98-2ChEMBLCHEMBL1688243PubChem49871007

Structure

InChIKeyZMCJFJZOSKEMOM-DNKZPPIMSA-NSMILESCCO[C@@H]1CC2=CC(=CC=C2[C@H]1N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)C1=C(C)N=CN=C1C)C(F)(F)F

Targets

P51681CCR5

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1Clinical trialPhase, status and sponsor resolved per trial

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with INCB-9471, and which of those have an active Phase 3 trial?

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