Identification
- Generic Name
- Viral Macrophage-Inflammatory Protein
- DrugBank Accession Number
- DB15748
- Background
Viral macrophage inflammatory protein-II (vMIP) is a highly basic protein and human chemokine analog encoded by human herpesvirus-8. The structure of vMIP consists of 71 residues and is a monomer under most conditions. It helps its virus evade the host immune system through selectively blocking and activating different receptors, preferentially inhibiting acute Th1-associated inflammation while also upregulating Th2 associated immune response.
- Type
- Biotech
- Groups
- Investigational
- Biologic Classification
- Protein Based Therapies
Peptides - Protein Chemical Formula
- Not Available
- Protein Average Weight
- Not Available
- Sequences
- Not Available
- Synonyms
- vCCL2
- Viral Macrophage Inflammatory Protein-II
- vMIP
- vMIP-II
- External IDs
- Viral Macrophage-Inflammatory Protein
Pharmacology
- Indication
Not Available
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Not Available
- Mechanism of action
This protein has the ability to bind to chemokine receptors (including both HIV coreceptors) and cell surface glycosaminoglycans. At the chemokine receptors, vMIP acts as an antagonist at CCR1, CCR2, CCR5, and CXCR4 while it is an agonist at CCR3 and CCR8. Due to its antagonistic action at CCR5 and CXCR4, vMIP is able to block HIV cell entry through these coreceptors while also inhibiting inflammation of monocytes and Th1 type T cells -- both major targets for HIV-1 and thus vMIP has potential to act as an HIV inhibitor. Glycosaminoglycans, on the other hand, are important as the binding to glycosaminoglycans may be essential for the protein to carry out its natural function in vivo.
vMIP is angiogenic -- its pro-angiogenic capabilities in mature and progenitor endothelial cells gives it potential for use in organ transplantations. It is also selectively chemotactic for Th2 lymphocytes. Overall, the major role of vMIP-II is regulation of immune responses.
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- Not Available
- Kingdom
- Organic Compounds
- Super Class
- Organic Acids
- Class
- Carboxylic Acids and Derivatives
- Sub Class
- Amino Acids, Peptides, and Analogues
- Direct Parent
- Peptides
- Alternative Parents
- Not Available
- Substituents
- Not Available
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- Not Available
- CAS number
- Not Available
References
- General References
- Zhao B, Liwang PJ: Characterization of the interactions of vMIP-II, and a dimeric variant of vMIP-II, with glycosaminoglycans. Biochemistry. 2010 Aug 24;49(33):7012-22. doi: 10.1021/bi100549y. [Article]
- Singh UP, Singh S, Ravichandran P, Taub DD, Lillard JW Jr: Viral macrophage-inflammatory protein-II: a viral chemokine that differentially affects adaptive mucosal immunity compared with its mammalian counterparts. J Immunol. 2004 Nov 1;173(9):5509-16. doi: 10.4049/jimmunol.173.9.5509. [Article]
- External Links
- Not Available
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
Drug created at August 11, 2020 21:51 / Updated at August 13, 2020 07:02