Sialidase-1

BE0000914ProteinHumansNEU1

Lysosomal exo-alpha-sialidase that catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. It is acted on by 3 drugs in DrugBank.

Gene name
NEU1
UniProtKB entry
Q99519Swiss-Prot
Cellular location
Lysosome lumen
Residues / weight
415 residues · 45,467 Da
Also known as
3.2.1.18 · Acetylneuraminyl hydrolase · G9 sialidase · Lysosomal neuraminidase · Lysosomal sialidase

Resolves to

Protein
UniProtQ99519UniProt nameNEUR1_HUMAN
Gene
HGNCHGNC:7758NCBI Gene4758GenBank2773339GeneCardsNEU1
Pharmacology
IUPHAR/GtoPdb3214KEGGhsa:4758
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sialidase-1, how selective are they, and which programs against it are still in active trials?

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