Proteinase-activated receptor 1

BE0000928ProteinHumansF2R

High affinity receptor that binds the activated thrombin, leading to calcium release from intracellular stores (PubMed:1672265, PubMed:8136362). It is acted on by 6 drugs in DrugBank.

Gene name
F2R
UniProtKB entry
P25116Swiss-Prot
Cellular location
Cell membrane
Residues / weight
425 residues · 47,440 Da
Also known as
CF2R · Coagulation factor II receptor · PAR-1 · PAR1 · Thrombin receptor

Resolves to

Protein
UniProtP25116UniProt namePAR1_HUMAN
Gene
HGNCHGNC:3537NCBI Gene2149GenBank339677GeneCardsF2R
Pharmacology
IUPHAR/GtoPdb347KEGGhsa:2149
Structure
PDB1NRNPDB1NROPDB1NRP
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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18GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Proteinase-activated receptor 1, how selective are they, and which programs against it are still in active trials?

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