Streptokinase is a purified fibrinolytic bacterial protein used to breakdown thrombosis in myocardial infarction, pulmonary embolism, and venous thromboembolism. Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci.
- Mechanism
- Curator reviewed
Plasminogen is an inactive molecule that becomes activated to plasmin when the Arg/Val bond is cleaved. Plasmin breaks down fibrin clots created by the blood clotting cascade. Streptokinase forms a highly specific 1:1 enzymatic complex with plasminogen which converts inactive plasminogen molecules into active plasmin. Plasmin degrades fibrin clots as well as fibrinogen and other plasma proteins. This in turn leads to the degradation of blood clots.
- Primary indication
- For the treatment of acute evolving transmural myocardial infarction, pulmonary embolism, deep vein thrombosis, arterial thrombosis or emolism and occlusion of arteriovenous cannulaeCurator reviewed · 21 structured indications
- Formula / weight
- C2100H3278N566O669S4 · 47286.7 Da
- First approval
- Canada, 1997
- Also known as
- Streptococcal fibrinolysin
Resolves to
What you can answer from here — as of July 17, 2026
Which drugs share a target with Streptokinase, and which of those have an active Phase 3 trial?
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