Thrombin is a coagulation factor used to stop bleeding during surgery. Also known as coagulation factor II, thrombin is a serine protease that plays a physiological role in regulating hemostasis and maintaining blood coagulation.
- Mechanism
- Curator reviewed
Bovine thrombin requires no intermediate physiological agent for its action. It activates platelets and catalyzes the conversion of fibrinogen to fibrin, which are essential steps for clot formation. Failure to clot blood occurs in the case where the primary clotting defect is the absence of fibrinogen itself. The speed with which the bovine thrombin clots blood is dependent upon the concentration of both the bovine thrombin and the fibrinogen present.
- Primary indication
- Bovine thrombin is a topical thrombin indicated to aid hemostasis whenever oozing blood and minor bleeding from capillaries and small venules is accessible and control of bleeding by standard surgical techniques (like suture, ligature, or...Curator reviewed · 2 structured indications
- First approval
- Canada, 2001 · United States, 1995
- Also known as
- coagulation factor II · Thrombin bovine · Thrombin, Topical (Bovine)
- Brand names
Resolves to
What you can answer from here — as of February 01, 2025
Which drugs share a target with Thrombin, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account