Cubilin

BE0000936ProteinHumansCUBN

Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake (PubMed:10371504, PubMed:11606717, PubMed:11717447, PubMed:14576052, PubMed:9572993). It is acted on by 3 drugs in DrugBank.

Gene name
CUBN
UniProtKB entry
O60494Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
3,623 residues · 398,733 Da
Also known as
460 kDa receptor · IFCR · Intestinal intrinsic factor receptor · Intrinsic factor-cobalamin receptor · Intrinsic factor-vitamin B12 receptor

Resolves to

Protein
UniProtO60494UniProt nameCUBN_HUMAN
Gene
HGNCHGNC:2548NCBI Gene8029GenBank3929529GeneCardsCUBN
Pharmacology
KEGGhsa:8029
Structure
PDB3KQ4PDB6GJE
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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18GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cubilin, how selective are they, and which programs against it are still in active trials?

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