Cathepsin B

BE0000939ProteinHumansCTSB

Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). It is acted on by 16 drugs in DrugBank.

Gene name
CTSB
UniProtKB entry
P07858Swiss-Prot
Cellular location
Lysosome
Residues / weight
339 residues · 37,821 Da
Also known as
3.4.22.1 · APP secretase · APPS · Cathepsin B1 · CPSB

Resolves to

Protein
UniProtP07858UniProt nameCATB_HUMAN
Gene
HGNCHGNC:2527NCBI Gene1508GenBank181192GeneCardsCTSB
Pharmacology
IUPHAR/GtoPdb2343KEGGhsa:1508
Structure
PDB1CSBPDB1GMYPDB1HUC
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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37+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cathepsin B, how selective are they, and which programs against it are still in active trials?

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