Interleukin-8

BE0000961ProteinHumansCXCL8

Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection (PubMed:18692776, PubMed:7636208). It is acted on by 9 drugs in DrugBank.

Gene name
CXCL8
UniProtKB entry
P10145Swiss-Prot
Cellular location
Secreted
Residues / weight
99 residues · 11,098 Da
Also known as
C-X-C motif chemokine 8 · Chemokine (C-X-C motif) ligand 8 · Emoctakin · GCP-1 · Granulocyte chemotactic protein 1

Resolves to

Protein
UniProtP10145UniProt nameIL8_HUMAN
Gene
HGNCHGNC:6025NCBI Gene3576GenBank34519GeneCardsCXCL8
Pharmacology
KEGGhsa:3576
Structure
PDB1ICWPDB1IKLPDB1IKM
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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48Clinical trialsTrials of drugs acting on it, by phase and status
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16GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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43+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Interleukin-8, how selective are they, and which programs against it are still in active trials?

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