Lactoylglutathione lyase

BE0000962ProteinHumansGLO1

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:20454679, PubMed:23122816, PubMed:9705294). It is acted on by 12 drugs in DrugBank.

Gene name
GLO1
UniProtKB entry
Q04760Swiss-Prot
Residues / weight
184 residues · 20,778 Da
Also known as
4.4.1.5 · Aldoketomutase · Glx I · Glyoxalase I · Ketone-aldehyde mutase

Resolves to

Protein
UniProtQ04760UniProt nameLGUL_HUMAN
Gene
HGNCHGNC:4323NCBI Gene2739GenBank219664GeneCardsGLO1
Pharmacology
KEGGhsa:2739
Structure
PDB1BH5PDB1FROPDB1QIN
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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44+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Lactoylglutathione lyase, how selective are they, and which programs against it are still in active trials?

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