Azosemide

DB08961InvestigationalSmall molecule

Azosemide is a loop diuretic used to treat hypertension, edema, and ascites.

Mechanism: Exact mechanism of action is unclear. However, it acts primarily on the loop of Henle, in both the medullary and cortical segments of the thick ascending limb.
Curator reviewed
Formula / weight: C₁₂H₁₁ClN₆O₂S₂ · 370.838 g/mol (avg)

Resolves to

Compound

UNIIMR40VT1L8ZCAS27589-33-9ChEMBLCHEMBL1097235ChEBI31248PubChem2273

Clinical / RWD

RxNorm18651

Structure

InChIKeyHMEDEBAJARCKCT-UHFFFAOYSA-NSMILESNS(=O)(=O)C1=C(Cl)C=C(NCC2=CC=CS2)C(=C1)C1=NNN=N1

Targets

P55011SLC12A2

Transporters

O15375SLC16A5

What you can answer from here — as of July 03, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1TransporterSubstrate / inhibitor direction, not just membership

Listed above

982Drug interactionsStructured to mechanism, not free text

1Clinical trialPhase, status and sponsor resolved per trial

8+ReferencesStructured and connected to the statements they support

Which drugs share a target with Azosemide, and which of those have an active Phase 3 trial?

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