Beta-glucuronidase

BE0000972ProteinHumansGUSB

Plays an important role in the degradation of dermatan and keratan sulfates. It is acted on by 6 drugs in DrugBank.

Gene name
GUSB
UniProtKB entry
P08236Swiss-Prot
Cellular location
Lysosome
Residues / weight
651 residues · 74,731 Da
Also known as
3.2.1.31 · Beta-G1

Resolves to

Protein
UniProtP08236UniProt nameBGLR_HUMAN
Gene
HGNCHGNC:4696NCBI Gene2990GenBank183233GeneCardsGUSB
Pharmacology
KEGGhsa:2990
Structure
PDB1BHGPDB3HN3
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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7GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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37+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Beta-glucuronidase, how selective are they, and which programs against it are still in active trials?

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