Sphingomyelin phosphodiesterase

BE0000973ProteinHumansSMPD1

Converts sphingomyelin to ceramide (PubMed:12563314, PubMed:1840600, PubMed:18815062, PubMed:25339683, PubMed:25920558, PubMed:27659707, PubMed:33163980). It is acted on by 8 drugs in DrugBank.

Gene name
SMPD1
UniProtKB entry
P17405Swiss-Prot
Cellular location
Lysosome
Residues / weight
631 residues · 69,936 Da
Also known as
3.1.4.12 · 3.1.4.3 · Acid sphingomyelinase · ASM · aSMase

Resolves to

Protein
UniProtP17405UniProt nameASM_HUMAN
Gene
HGNCHGNC:11120NCBI Gene6609GenBank179095GeneCardsSMPD1
Pharmacology
IUPHAR/GtoPdb2514KEGGhsa:6609
Structure
PDB5I81PDB5I85PDB5I8R
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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22GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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52+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sphingomyelin phosphodiesterase, how selective are they, and which programs against it are still in active trials?

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