Interleukin-12 subunit beta

BE0000981ProteinHumansIL12B

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. It is acted on by 6 drugs in DrugBank.

Gene name
IL12B
UniProtKB entry
P29460Swiss-Prot
Cellular location
Secreted
Residues / weight
328 residues · 37,169 Da
Also known as
CLMF p40 · Cytotoxic lymphocyte maturation factor 40 kDa subunit · IL-12 subunit p40 · IL-12B · NK cell stimulatory factor chain 2

Resolves to

Protein
UniProtP29460UniProt nameIL12B_HUMAN
Gene
HGNCHGNC:5970NCBI Gene3593GenBank180626GeneCardsIL12B
Pharmacology
KEGGhsa:3593
Structure
PDB1F42PDB1F45PDB3D85
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
3Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
16GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
24+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Interleukin-12 subunit beta, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In