Catenin beta-1

BE0000985ProteinHumansCTNNB1

Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). It is acted on by 3 drugs in DrugBank.

Gene name
CTNNB1
UniProtKB entry
P35222Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
781 residues · 85,496 Da
Also known as
Beta-catenin · CTNNB

Resolves to

Protein
UniProtP35222UniProt nameCTNB1_HUMAN
Gene
HGNCHGNC:2514NCBI Gene1499GenBank860988GeneCardsCTNNB1
Pharmacology
KEGGhsa:1499
Structure
PDB1G3JPDB1JDHPDB1JPW
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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7Clinical trialsTrials of drugs acting on it, by phase and status
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74GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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84+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Catenin beta-1, how selective are they, and which programs against it are still in active trials?

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