Sodium/calcium exchanger 1

BE0000986ProteinHumansSLC8A1

Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:11241183, PubMed:1374913, PubMed:1476165). It is acted on by 9 drugs in DrugBank.

Gene name
SLC8A1
UniProtKB entry
P32418Swiss-Prot
Cellular location
Cell membrane
Residues / weight
973 residues · 108,546 Da
Also known as
CNC · Na(+)/Ca(2+)-exchange protein 1 · NCX1 · Solute carrier family 8 member 1

Resolves to

Protein
UniProtP32418UniProt nameNAC1_HUMAN
Gene
HGNCHGNC:11068NCBI Gene6546GenBank180673GeneCardsSLC8A1
Pharmacology
IUPHAR/GtoPdb945KEGGhsa:6546
Structure
PDB8JP0PDB8SGIPDB8SGJ
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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19GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium/calcium exchanger 1, how selective are they, and which programs against it are still in active trials?

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