NAV

Cibenzoline

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Cibenzoline
DrugBank Accession Number
DB13358
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
3D
Similar Structures
Weight
Average: 262.356
Monoisotopic: 262.146998588
Chemical Formula
C18H18N2
Synonyms
  • Cibenzoline
  • Cifenline
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Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
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AcarboseThe risk or severity of hypoglycemia can be increased when Cibenzoline is combined with Acarbose.
AcebutololAcebutolol may increase the arrhythmogenic activities of Cibenzoline.
AcetohexamideThe risk or severity of hypoglycemia can be increased when Cibenzoline is combined with Acetohexamide.
AcetyldigitoxinAcetyldigitoxin may increase the arrhythmogenic activities of Cibenzoline.
AcrivastineThe risk or severity of QTc prolongation can be increased when Acrivastine is combined with Cibenzoline.
Food Interactions
Not Available

Categories

ATC Codes
C01BG07 — Cibenzoline
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Diphenylmethanes
Direct Parent
Diphenylmethanes
Alternative Parents
Imidolactams / Imidazolines / Propargyl-type 1,3-dipolar organic compounds / Carboximidamides / Carboxamidines / Azacyclic compounds / Organopnictogen compounds / Hydrocarbon derivatives
Substituents
2-imidazoline / Amidine / Aromatic heteromonocyclic compound / Azacycle / Carboximidamide / Carboxylic acid amidine / Diphenylmethane / Hydrocarbon derivative / Imidolactam / Organic 1,3-dipolar compound
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
Z7489237QT
CAS number
53267-01-9
InChI Key
IPOBOOXFSRWSHL-UHFFFAOYSA-N
InChI
InChI=1S/C18H18N2/c1-3-7-14(8-4-1)18(15-9-5-2-6-10-15)13-16(18)17-19-11-12-20-17/h1-10,16H,11-13H2,(H,19,20)
IUPAC Name
2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole
SMILES
C1C(C2=NCCN2)C1(C1=CC=CC=C1)C1=CC=CC=C1

References

General References
Not Available
ChemSpider
2645
BindingDB
50151856
RxNav
21099
ChEBI
135083
ChEMBL
CHEMBL87045
Wikipedia
Cibenzoline

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedNot AvailableParoxysmal Atrial Fibrillation (PAF)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00485 mg/mLALOGPS
logP3.97ALOGPS
logP3Chemaxon
logS-4.7ALOGPS
pKa (Strongest Basic)10.41Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area24.39 Å2Chemaxon
Rotatable Bond Count3Chemaxon
Refractivity91.45 m3·mol-1Chemaxon
Polarizability29.65 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSsplash10-0fto-2910000000-c47bf9b38aabf9e71f65
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-03dl-0980000000-d1fa7c78309041dad8f1
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-03dl-0980000000-28e0f49fa3328f165485
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-03di-0290000000-8c6c5e869071a902f41b
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-03di-0390000000-450247b26c0b5182aa85
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-014l-1900000000-cc9c4498146fcc45666b
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-014i-0900000000-60402ab8b1a174771bba
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-159.76608
predicted
DeepCCS 1.0 (2019)
[M+H]+162.12408
predicted
DeepCCS 1.0 (2019)
[M+Na]+168.21724
predicted
DeepCCS 1.0 (2019)

Drug created at June 23, 2017 20:40 / Updated at February 21, 2021 18:54