Thiopurine S-methyltransferase

BE0000987ProteinHumansTPMT

Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor (PubMed:18484748, PubMed:657528). It is acted on by 8 drugs in DrugBank.

Gene name
TPMT
UniProtKB entry
P51580Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
245 residues · 28,180 Da
Also known as
2.1.1.67 · Thiopurine methyltransferase

Resolves to

Protein
UniProtP51580UniProt nameTPMT_HUMAN
Gene
HGNCHGNC:12014NCBI Gene7172GenBank386420GeneCardsTPMT
Pharmacology
KEGGhsa:7172
Structure
PDB2BZGPDB2H11
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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6Clinical trialsTrials of drugs acting on it, by phase and status
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8Metabolic reactionsDrug transformations it catalyses, substrate to product
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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41+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Thiopurine S-methyltransferase, how selective are they, and which programs against it are still in active trials?

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