Phospholipid-transporting ATPase IA

BE0001001ProteinHumansATP8A1

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric... It is acted on by 1 drug in DrugBank.

Gene name
ATP8A1
UniProtKB entry
Q9Y2Q0Swiss-Prot
Cellular location
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane
Residues / weight
1,164 residues · 131,368 Da
Also known as
7.6.2.1 · ATPase class I type 8A member 1 · ATPIA · Chromaffin granule ATPase II · P4-ATPase flippase complex alpha subunit ATP8A1

Resolves to

Protein
UniProtQ9Y2Q0UniProt nameAT8A1_HUMAN
Gene
HGNCHGNC:13531NCBI Gene10396GenBank4972583GeneCardsATP8A1
Pharmacology
KEGGhsa:10396
Structure
PDB6K7GPDB6K7HPDB6K7I
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phospholipid-transporting ATPase IA, how selective are they, and which programs against it are still in active trials?

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