Amine oxidase [copper-containing] 3

BE0001002ProteinHumansAOC3

Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia (PubMed:19588076, PubMed:24304424, PubMed:9653080). It is acted on by 9 drugs in DrugBank.

Gene name
AOC3
UniProtKB entry
Q16853Swiss-Prot
Cellular location
Cell membrane
Residues / weight
763 residues · 84,621 Da
Also known as
1.4.3.21 · Amine oxidase copper-containing 3 · Copper amine oxidase · HPAO · Semicarbazide-sensitive amine oxidase

Resolves to

Protein
UniProtQ16853UniProt nameAOC3_HUMAN
Gene
HGNCHGNC:550NCBI Gene8639GenBank1399032GeneCardsAOC3
Pharmacology
IUPHAR/GtoPdb2767KEGGhsa:8639
Structure
PDB1PU4PDB1US1PDB2C10
Drugs

What you can answer from here — as of September 03, 2024

9DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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47+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Amine oxidase [copper-containing] 3, how selective are they, and which programs against it are still in active trials?

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