Coagulation factor XI

BE0001021ProteinHumansF11

Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. It is acted on by 22 drugs in DrugBank.

Gene name
F11
UniProtKB entry
P03951Swiss-Prot
Cellular location
Secreted
Residues / weight
625 residues · 70,109 Da
Also known as
3.4.21.27 · FXI · Plasma thromboplastin antecedent · PTA

Resolves to

Protein
UniProtP03951UniProt nameFA11_HUMAN
Gene
HGNCHGNC:3529NCBI Gene2160GenBank182833GeneCardsF11
Pharmacology
IUPHAR/GtoPdb2360KEGGhsa:2160
Structure
PDB1XX9PDB1XXDPDB1XXF
Drugs

What you can answer from here — as of September 07, 2019

22DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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65+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Coagulation factor XI, how selective are they, and which programs against it are still in active trials?

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