G1/S-specific cyclin-D1

BE0001027ProteinHumansCCND1

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:33854235, PubMed:8114739, PubMed:8302605). It is acted on by 6 drugs in DrugBank.

Gene name
CCND1
UniProtKB entry
P24385Swiss-Prot
Cellular location
Nucleus
Residues / weight
295 residues · 33,729 Da
Also known as
B-cell lymphoma 1 protein · BCL-1 · BCL-1 oncogene · BCL1 · PRAD1

Resolves to

Protein
UniProtP24385UniProt nameCCND1_HUMAN
Gene
HGNCHGNC:1582NCBI Gene595GenBank35632GeneCardsCCND1
Pharmacology
KEGGhsa:595
Structure
PDB2W96PDB2W99PDB2W9F
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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18Clinical trialsTrials of drugs acting on it, by phase and status
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17GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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36+ReferencesStructured and connected to the statements they support
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Which approved drugs act on G1/S-specific cyclin-D1, how selective are they, and which programs against it are still in active trials?

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