Ferrochelatase, mitochondrial

BE0001033ProteinHumansFECH

Catalyzes the ferrous insertion into protoporphyrin IX and participates in the terminal step in the heme biosynthetic pathway. It is acted on by 7 drugs in DrugBank.

Gene name
FECH
UniProtKB entry
P22830Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
423 residues · 47,862 Da
Also known as
4.98.1.1 · Heme synthase · Protoheme ferro-lyase

Resolves to

Protein
UniProtP22830UniProt nameHEMH_HUMAN
Gene
HGNCHGNC:3647NCBI Gene2235GenBank219656GeneCardsFECH
Pharmacology
KEGGhsa:2235
Structure
PDB1HRKPDB2HRCPDB2HRE
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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35+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ferrochelatase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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