Protein-glutamine gamma-glutamyltransferase 2

BE0001035ProteinHumansTGM2

Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively (PubMed:23941696,... It is acted on by 11 drugs in DrugBank.

Gene name
TGM2
UniProtKB entry
P21980Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
687 residues · 77,328 Da
Also known as
2.3.2.13 · Erythrocyte transglutaminase · G(h) · Heart G alpha(h) · hhG alpha(h)

Resolves to

Protein
UniProtP21980UniProt nameTGM2_HUMAN
Gene
HGNCHGNC:11778NCBI Gene7052GenBank339521GeneCardsTGM2
Pharmacology
IUPHAR/GtoPdb3015KEGGhsa:7052
Structure
PDB1KV3PDB2Q3ZPDB3LY6
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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12GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protein-glutamine gamma-glutamyltransferase 2, how selective are they, and which programs against it are still in active trials?

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