GTP cyclohydrolase 1

BE0001055ProteinHumansGCH1

Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). It is acted on by 4 drugs in DrugBank.

Gene name
GCH1
UniProtKB entry
P30793Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
250 residues · 27,903 Da
Also known as
3.5.4.16 · DYT5 · GCH · GTP cyclohydrolase I · GTP-CH-I

Resolves to

Protein
UniProtP30793UniProt nameGCH1_HUMAN
Gene
HGNCHGNC:4193NCBI Gene2643GenBank7242659GeneCardsGCH1
Pharmacology
KEGGhsa:2643
Structure
PDB1FB1PDB6Z80PDB6Z85
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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22GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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65+ReferencesStructured and connected to the statements they support
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Which approved drugs act on GTP cyclohydrolase 1, how selective are they, and which programs against it are still in active trials?

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