Explore a selection of our essential drug information below, or:
Identification
- Summary
Isopropyl alcohol is an antiseptic and disinfectant used in a variety of clinical and domestic settings.
- Brand Names
- Adrenalin, Avonex, Benefix, Cyltezo, Duraprep, Elevidys, Humira, Kenalog, Lupaneta Pack 1-month, Lupron, Marbeta, Meijer, P-Care M, P-Care MG, P-care, P-care X, Simlandi, Venipuncture Px1, Xyntha, Zolgensma Kit 2.6 - 3.0 Kg
- Generic Name
- Isopropyl alcohol
- DrugBank Accession Number
- DB02325
- Background
An isomer of 1-propanol. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Structure
Structure for Isopropyl alcohol (DB02325)
- Weight
- Average: 60.095
Monoisotopic: 60.057514878 - Chemical Formula
- C3H8O
- Synonyms
- 2-Propanol
- Alcohol isopropílico
- Isopropanol
- Isopropyl alcohol
- External IDs
- FEMA NO. 2929
- NSC-135801
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination to prevent Infection Combination Product in combination with: Iodine (DB05382) •••••••••••• •••••••• Used as adjunct in combination for therapy Infection Combination Product in combination with: Iodine (DB05382) •••••••••••• •••••••• Prophylaxis of Infection ••• ••• - Associated Therapies
- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism ANitric oxide synthase 3 inhibitorHumans AOxysterols receptor LXR-beta inhibitorHumans AHeme oxygenase 1 inhibitorHumans AGTP cyclohydrolase 1 inhibitorHumans APhospholipase A2, membrane associated inhibitorHumans ATumor necrosis factor inhibitorHumans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- International/Other Brands
- Isopro
- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image 1 Hotel Hand Sanitizer Gel 100 mL/100mL Topical PhytogenX, Inc. 2020-08-24 Not applicable US 
1000 Wet Wipes Cloth 2825 g/10001 Topical JIANGSU MEIFAN BIOTECHNOLOGY CO., LTD. 2020-11-11 Not applicable US 1000 Wet Wipes Cloth 2.82 kg/10001 Topical JIANGSU MEIFAN BIOTECHNOLOGY CO., LTD. 2020-11-09 Not applicable US 108 Hand Sanitizer Liquid 75 mL/100mL Topical JAMESTOWN PAINT COMPANY 2020-03-30 Not applicable US 16oz Isopropyl Alcohol Liquid 70 mL/70mL Topical Collective Science Integration 2020-09-24 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 25 Person ANSI Isopropyl alcohol (70 mL/100mL) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (0.40 mL/100mL) + Benzocaine (6 mL/100mL) + Ethanol (60 mL/100mL) + Ethanol (62 g/100g) + Ibuprofen (200 mg/1) + Lidocaine (0.5 g/100g) + Neomycin sulfate (5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL) Kit Ophthalmic; Oral; Topical Genuine First Aid 2010-04-25 Not applicable US 3M DuraPrep Surgical Isopropyl alcohol (636.4 mg/1mL) + Iodine povacrylex (6.02 mg/1mL) Solution Topical Solventum US LLC 2006-09-29 Not applicable US 3M DURAPREP® SURGICAL SOLUTION Isopropyl alcohol (60.61 % v/v) + Iodine (0.12 % v/v) Solution Topical 3M COLOMBIA S.A. 2006-11-10 2015-08-03 Colombia 
3M SoluPrep Isopropyl alcohol (0.7 mL/1mL) + Chlorhexidine gluconate (20 mg/1mL) Solution Topical 3M Company 2018-10-08 2020-09-30 US 3M SoluPrep Isopropyl alcohol (0.7 mL/1mL) + Chlorhexidine gluconate (20 mg/1mL) Solution Topical 3M Company 2018-10-08 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 4047 Fist Aid Kit Isopropyl alcohol (0.7 mL/1mL) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) Kit Topical Honeywell Safety Products USA, Inc 2018-11-24 2019-10-18 US 4048 Fist Aid Kit Isopropyl alcohol (0.7 mL/1mL) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) Kit Topical Honeywell Safety Products USA, Inc 2018-11-24 2019-10-18 US 4051 First Aid Kit Isopropyl alcohol (0.7 mL/1mL) + Benzalkonium chloride (0.13 g/100g) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Lidocaine hydrochloride (20 mg/1mL) + Neomycin sulfate (3.5 mg/1g) Kit Topical Honeywell Safety Products USA, Inc 2018-11-21 2019-10-18 US 4052 First Aid Kit Isopropyl alcohol (0.7 mL/1mL) + Benzalkonium chloride (0.13 g/100g) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Lidocaine hydrochloride (20 mg/1mL) + Neomycin sulfate (3.5 mg/1g) Kit Topical Honeywell Safety Products USA, Inc 2018-11-21 2019-10-18 US 4072First Aid Kit Isopropyl alcohol (0.7 mL/1mL) Kit Topical Honeywell Safety Products USA, Inc 2018-11-06 Not applicable US
Categories
- ATC Codes
- D08AX05 — Isopropanol
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as secondary alcohols. These are compounds containing a secondary alcohol functional group, with the general structure HOC(R)(R') (R,R'=alkyl, aryl).
- Kingdom
- Organic compounds
- Super Class
- Organic oxygen compounds
- Class
- Organooxygen compounds
- Sub Class
- Alcohols and polyols
- Direct Parent
- Secondary alcohols
- Alternative Parents
- Hydrocarbon derivatives
- Substituents
- Aliphatic acyclic compound / Hydrocarbon derivative / Secondary alcohol
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- secondary alcohol (CHEBI:17824) / a small molecule (ISO-PROPANOL)
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- ND2M416302
- CAS number
- 67-63-0
- InChI Key
- KFZMGEQAYNKOFK-UHFFFAOYSA-N
- InChI
- InChI=1S/C3H8O/c1-3(2)4/h3-4H,1-2H3
- IUPAC Name
- propan-2-ol
- SMILES
- CC(C)O
References
- Synthesis Reference
http://en.wikipedia.org/wiki/Alcohol#Laboratory_synthesis
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0000863
- KEGG Drug
- D00137
- KEGG Compound
- C01845
- PubChem Compound
- 3776
- PubChem Substance
- 46508136
- ChemSpider
- 3644
- 797541
- ChEBI
- 17824
- ChEMBL
- CHEMBL582
- ZINC
- ZINC000000901159
- PharmGKB
- PA450117
- PDBe Ligand
- IPA
- Wikipedia
- Isopropyl_alcohol
- PDB Entries
- 1ak9 / 1am7 / 1aqn / 1asw / 1au9 / 1bnd / 1bw9 / 1c1d / 1c1x / 1ci8 … show 753 more
- MSDS
- Download (51.8 KB)
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample dataNot Available Active Not Recruiting Not Available Infantile Spinal Muscular Atrophy, Type I [Werdnig- Hoffman] 1 somestatus stop reason just information to hide Not Available Completed Not Available Drying Time 1 somestatus stop reason just information to hide Not Available Completed Not Available To Treat the Vomiting Frequently Occur Post-laparoscopic by Different Anti Emetic Drugs 1 somestatus stop reason just information to hide Not Available Completed Prevention Bacteremia 1 somestatus stop reason just information to hide Not Available Completed Prevention Colonization 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- B. Braun Melsungen AG
- Derm Buro Inc.
- Medical Components Inc.
- Medical Techniques LLC
- Smiths Medical ASD Inc.
- Dosage Forms
Form Route Strength Cloth Topical 2.82 kg/10001 Cloth Topical 2825 g/10001 Liquid Topical 70 mL/70mL Cloth Topical 0.594 kg/2001 Cloth Topical 1130 g/4001 Kit Topical 0.7 mL/1mL Cream; kit; swab Topical Kit Respiratory (inhalation); Topical Cream; kit; liquid; ointment; swab Ophthalmic; Topical Gel; kit; liquid; swab Topical Cream; kit; liquid; ointment; swab Topical Kit; swab Topical 0.7 mL/1mL Kit Ophthalmic; Oral; Respiratory (inhalation); Topical Cream; kit; liquid; ointment; swab; tablet Ophthalmic; Oral; Topical Kit; liquid; ointment; spray; swab; tablet Ophthalmic; Oral; Topical Kit; liquid; lozenge; ointment; spray; swab; tablet Ophthalmic; Oral; Topical Gel; kit; liquid; ointment; swab Ophthalmic; Topical Kit Ophthalmic; Respiratory (inhalation); Topical Cream; inhalant; kit; swab; tablet Oral; Respiratory (inhalation); Topical Kit Oral; Respiratory (inhalation); Topical Gel; kit; swab Topical Cream; kit; liquid; swab Ophthalmic; Topical Inhalant; kit; liquid; ointment; spray; swab Ophthalmic; Respiratory (inhalation); Topical Cream; kit; liquid; ointment; swab; tablet Oral; Topical Inhalant; kit; liquid; ointment; spray; swab; tablet Ophthalmic; Oral; Respiratory (inhalation); Topical Cream; kit; ointment; swab Topical Kit; liquid; ointment; swab; tablet Ophthalmic; Oral; Topical Gel; kit; liquid; ointment; solution; swab Ophthalmic; Topical Kit; liquid; ointment; swab Topical Gel; kit; liquid; swab Ophthalmic; Topical Kit; liquid; swab Ophthalmic; Topical Kit; liquid; ointment; spray; swab Ophthalmic; Topical Kit; liquid; ointment; swab Ophthalmic; Topical Kit; liquid; ointment; swab; tablet Oral; Topical Cream; gel; kit; liquid; ointment; spray; swab Ophthalmic; Topical Cream; kit; liquid; ointment; spray; swab Ophthalmic; Topical Gel; kit; liquid; ointment; swab; tablet Oral; Topical Kit Irrigation; Ophthalmic; Respiratory (inhalation); Topical Cream; irrigant; kit; liquid; ointment; swab Irrigation; Ophthalmic; Topical Irrigant; kit; liquid; swab Irrigation; Ophthalmic; Topical Kit Irrigation; Oral; Respiratory (inhalation); Topical Kit Irrigation; Ophthalmic; Oral; Respiratory (inhalation); Topical Solution Topical 500 mg/1mL Cloth Topical 1.07 mL/1 Liquid Topical 70 g/100mL Spray Topical 700 mg/1mL Solution Topical 1 mL/700mg Solution Topical 44.4 mL/60mL Cloth Topical 3.15 mL/1 Solution Topical 999 mL/1000mL Cream Topical Injection, solution; kit Infiltration; Intramuscular; Intravenous; Perineural; Topical Injection, solution; kit Infiltration; Intramuscular; Perineural; Topical Injection, solution; kit Intramuscular; Intravenous; Topical Cloth Topical 1 mL/100mL Spray Topical 0.6 mL/1mL Kit Intramuscular; Intraocular; Subcutaneous Lotion Topical 0.7575 g/1mL Solution Topical 70 mL/100mL Liquid Topical 62.0 % Gel Topical 62 mL/100mL Liquid Topical 0.99 mL/1mL Liquid Topical 60 mg/1mL Patch Topical 700 mg/1g Swab Topical .70 g/1g Swab Topical 7 mL/10mL Solution Topical 70.7 mL Cloth Topical 70 g/100g Swab Topical 700 mg/1g Gel Topical 700 mL/1000mL Swab Topical 0.7 1/1 Swab Topical 0.70 mL/1 Swab Topical 70 mL/1 Cloth Topical 0.7 mL/0.7mL Cloth Topical 700 mg/1mL Swab Topical 70 1/1 Cloth Topical 0.70 mL/1mL Cloth Topical 70 g/1001 Liquid Topical 70 mL/100mL Sponge Topical 7 mL/10mL Swab Topical .70 mg/1mg Swab Topical 0.28 mL/0.4mL Swab Topical 0.56 mL/0.8mL Swab Topical 0.7 mL/1mL Swab Topical 0.7 mL/1 Swab Topical 0.8 g/0.8g Swab Topical 700 mg/1 Swab Topical 8 g/1 Swab Topical Cloth Topical 70 mg/1 Swab Extracorporeal; Topical 75 g/100g Liquid Topical 70 g/100g Cloth Topical 0.7 mL/1g Liquid Topical 70 % Swab Topical 1.4 mL/1 Swab Topical 70 mL/1g Swab Topical .70 mL/1 Swab Topical 0.70 g/1mL Cloth Extracorporeal 720 mL/2001 Gel Topical 70 % Lotion Topical 70 % Liquid Topical 21 mL / 30 mL Lotion Topical 75 mL/100mL Liquid Topical 76 mL/100mL Liquid Topical 760 g/1000mL Spray Topical 700 mg/1000mL Jelly Topical 50 % Injection, emulsion; kit Intravenous; Topical Gel Topical 2142.88 g/3380.08g Cloth Topical 1.4798 g/1.4798g Liquid Topical 0.56118 g/1mL Liquid Topical 715 mL/1L Liquid Topical 7000 L/10000L Liquid Topical 8000 L/10000L Gel Topical 70 mL/100mL Spray Topical 80 mL/100mL Solution / drops Auricular (otic) Kit Topical 70 mL/100mL Gel Topical 43 mL/60mL Patch Topical .70 mL/1mL Gel Topical 70 L/1L Kit Intramuscular Spray Topical 70 mL/60mL Gel Topical 100 mL/100mL Solution Topical 2076.54 g/3292.22g Liquid Topical 30 mg/30mL Swab Topical 70 % Injection, powder, lyophilized, for solution; kit Intravenous; Topical Kit Infiltration; Intra-articular; Intralesional; Intramuscular; Perineural; Topical Injection, solution; injection, suspension; kit; solution; swab Infiltration; Intra-articular; Intralesional; Intramuscular; Intrathecal; Intravascular; Intravenous; Topical Gel Topical 0.07 mL/1mL Spray Topical 0.75 mL/1mL Liquid Topical 0.7 L/1L Kit Epidural; Infiltration; Topical Kit Infiltration; Intra-articular; Intralesional; Intramuscular; Intrathecal; Intravascular; Intravenous; Perineural; Topical Gel Topical 754 mL/1000mL Solution, gel forming, extended release Topical Cloth; injection, solution; kit; solution Epidural; Infiltration; Intra-articular; Intramuscular; Topical Kit Electro-osmosis Liquid Topical 60 % Liquid Topical 63 % Gel Topical 94.8 mL/99mL Cloth; kit; ointment; swab Topical Gel Topical 2.8 L/4L Liquid Topical 0.754 L/1L Gel Topical 60 mL/100mL Solution Cutaneous Gel Topical 700 mg/1mL Spray Topical 42 mL/1 Gel Topical 0.8 L/1L Gel Topical 0.7 L/1L Spray Topical 45 mL/60mL Gel Extracorporeal Gel Topical 70 um/60mL Liquid Topical 70 mg/100mg Injection, solution; injection, suspension; kit Epidural; Intra-articular; Intracaudal; Intramuscular; Intravenous; Perineural; Topical Gel Topical 75 L/100L Liquid Topical 0.75 mL/1mL Liquid Topical 91 mL/100mL Liquid Auricular (otic) 950 mg/1mL Cloth Topical 0.7 g/1g Kit Oral Patch Topical 70 mL/100mL Swab Oral Injection, solution; kit; solution Epidural; Infiltration; Intracaudal; Perineural; Topical Liquid Auricular (otic) 95 mL/100mL Spray Topical 91 mL/100mL Swab Topical 70 g/100g Kit Infiltration; Intramuscular; Intravenous; Topical Injection, solution; kit; solution; swab Epidural; Infiltration; Intra-articular; Intracaudal; Intramuscular; Intrathecal; Intravascular; Intravenous; Perineural; Topical Kit Epidural; Infiltration; Intramuscular; Intravenous; Topical Liquid Extracorporeal Liquid Topical 50 mL/100mL Kit Intramuscular; Intravenous; Topical Solution Topical 660 mL/943mL Liquid Auricular (otic) 0.76 g/1mL Swab Topical 0.7 g/1mL Cloth Topical 70 % Kit Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical Injection, solution; injection, suspension; kit; solution; swab Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intrathecal; Intravascular; Intravenous; Perineural; Soft tissue; Topical Kit Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; Topical Kit Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical Injection, solution; injection, suspension; kit; solution; swab Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intrasynovial; Intrathecal; Intravascular; Intravenous; Perineural; Soft tissue; Topical Liquid Auricular (otic) 94.998 1/100mL Liquid Auricular (otic) Liquid Auricular (otic) 94.998 g/100mL Liquid Auricular (otic) 95 g/100mL Solution Topical 80 mL/100mL Gel Topical 177.75 mL/237mL Spray Topical 177.75 mL/237mL Swab Topical 70 mL/1001 Kit Intravenous Liquid Auricular (otic) 0.95 g/100g Gel Topical 62 g/100mL Gel Topical 65.5 g/100mL Solution Topical 89.4 mL/100mL Injection; kit; swab Intramuscular; Subcutaneous; Topical Kit Intramuscular; Subcutaneous Injection; kit Intramuscular; Subcutaneous; Topical Liquid Topical .70 L/100L Gel Topical 73 mL/100mL Cloth Topical 0.34 g/1 Liquid Topical 0.72 mL/1mL Liquid Topical 2838 mL/3780mL Cloth Topical 0.70 1/1 Kit Ophthalmic; Topical Injection, solution; kit Infiltration; Perineural; Topical Injection, solution; kit Perineural; Retrobulbar; Topical Liquid Topical 13 g/100g Aerosol, foam Topical Solution Topical 0.14 g/0.2mL Solution Topical 1.4 g/2mL Liquid Topical 28.66 mL/29mL Patch Topical 70 g/100g Patch Topical Swab Topical 75 g/100g Kit Oral; Topical Solution 75 % v/v Solution Topical 700 g/1000g Gel Topical 70 L/100L Solution Topical 75 mL/1L Spray Topical 75 L/100L Gel Topical 0.64 mL/1mL Liquid Topical 500 mg/1mL Liquid Topical 910 mg/1mL Kit Ophthalmic; Oral; Topical Swab Topical 0.07 mL/1mL Spray Topical 0.7 mL/1mL Liquid Topical 187.5 mL/250mL Gel Topical 2839 mL/3785mL Liquid Topical 2839 mL/3785mL Cloth Topical 0.45 1/1 Liquid Topical 350 g/100g Injection, solution; injection, suspension; kit Infiltration; Intra-articular; Intralesional; Intramuscular; Perineural; Topical Gel Topical 42 mL/60mL Gel Topical 0.722 mL/1mL Spray Topical 0.67 mL/50mL Aerosol Topical 75 mL/100mL Aerosol, spray Topical 75 mL/100mL Cloth Topical 0.85 1/1 Cloth Topical 75 mL/100mL Gel Extracorporeal 70 mL/100mL Gel Topical 0.705 mL/1mL Gel Topical 0.75 mL/1mL Gel Topical 14 mL/20mL Gel Topical 175 mL/250mL Gel Topical 21 mL/30mL Gel Topical 2800 mL/4000mL Gel Topical 350 mL/500mL Gel Topical 375 mL/500mL Gel Topical 42 mL/100mL Gel Topical 450 mL/450mL Gel Topical 64 mL/100mL Gel Topical 70 mL/70mL Gel Topical 70.1 mL/70.1mL Gel Topical 70.264 mL/100mL Gel Topical 70.92 mL/100mL Gel Topical 71 mL/100mL Gel Topical 71.7 mL/100mL Gel Topical 75.59 mL/100mL Gel Topical 75.69 mL/100mL Gel Topical 80 mL/100mL Gel Topical 87.5 mL/125mL Gel, metered Topical 75 mL/100mL Liquid Cutaneous 75 mL/100mL Liquid Cutaneous; Topical 75 mL/100mL Liquid Topical 1.325 L/1.893L Liquid Topical 14195.29 mL/18927.05mL Liquid Topical 148.38 L/197.84L Liquid Topical 156148.16 mL/208197.55mL Liquid Topical 2.835 L/3.78L Liquid Topical 27 mL/29mL Liquid Topical 2838 mL/3784mL Liquid Topical 2839.06 mL/3785.42mL Liquid Topical 2855.7 mL/3800mL Liquid Topical 3 L/4L Liquid Topical 3000 mL/4000mL Liquid Topical 3085.3 mL/3800mL Liquid Topical 3742.2 mL/3780mL Liquid Topical 375 mL/500mL Liquid Topical 7.5 L/10L Liquid Topical 70 1/1001 Liquid Topical 70.929 mL/100mL Liquid Topical 72 mL/100mL Liquid Topical 75 mL/200mL Liquid Topical 75.15 mL/100mL Liquid Topical 750 mL/1000mL Liquid Topical 750 mL/1L Liquid Topical 80 mL/100mL Liquid Topical 99 mL/99mL Lotion, augmented Topical 75 mL/100mL Ointment Topical 75 mL/100mL Solution Topical 2.835 L/3.78L Solution Topical 3.75 L/5L Solution Topical 375 mL/500mL Solution Topical 75 L/3.785L Solution Topical 75 L/100L Solution Topical 75 mL/75mL Solution Topical 75.6818 mL/100mL Solution Topical 7576 mL/10000mL Solution, concentrate Topical 99 mL/100mL Solution, gel forming / drops Cutaneous; Topical 75 mL/100mL Spray Topical Spray Topical 100 mL/100mL Spray Topical 150 mL/200mL Spray Topical 37.5 mL/50mL Spray Topical 41.3 mL/59mL Spray Topical 6.75 mL/9mL Spray Topical 67 mL/100mL Spray Topical 72 g/100g Spray Topical 75 kg/100kg Spray Topical 81.75 mL/109mL Spray, suspension Topical 75 mL/100mL Gel Extracorporeal; Topical 75 L/100L Gel Extracorporeal; Topical 75 mL/100mL Aerosol, foam Topical 75 mL/100mL Gel Topical 0.7 mL/1mL Solution Topical 0.75 kg/1kg Gel Topical 0.73 mL/1mL Solution Topical 0.75 mL/1mL Liquid Topical 60.67 mL/100mL Swab Topical 67 mL/1001 Cloth Topical 3.3 mL/1 Cloth Topical 70 1/1001 Liquid Topical 0.75 L/1L Solution Topical 1 mL/1mL Liquid Topical 80 g/100g Gel Topical 75 mL/100mL Gel Topical 62.09 mL/88.7mL Liquid Topical 700 mg/1mL Injection, solution; kit; swab Subcutaneous; Topical Injection, suspension; kit Subcutaneous; Topical Liquid Cutaneous 750 mL/1L Gel Topical 70.0 1/100L Gel Topical 75.0 L/100L Liquid Topical 70.0 L/100L Liquid Topical 75.0 L/100L Liquid Topical 75.0249 L/100L Liquid Topical 80.0992 L/100L Liquid Topical 80.1003 L/100L Liquid Topical 80.0691 L/100L Liquid Topical 75.0271 L/100L Gel Topical 75.0128 L/100L Gel Topical 80.0836 L/100L Gel Topical 80.0847 L/100L Liquid Topical 80.087 L/100L Gel Topical 75.015 L/100L Cloth Topical 70 mL/100g Kit Epidural; Infiltration; Intra-articular; Topical Solution Topical 0.57 1/1 Liquid Topical; Vaginal Liquid Topical 83 mL/100mL Liquid Topical 83 mL/100g Swab Topical 0.7 g/1 Swab Cutaneous; Topical 75 mL/100mL Swab Topical 75 mL/100mL Solution / drops Topical 0.95 g/100mL Gel Topical 72 mL/100mL Gel Topical 73.71 mL/100mL Gel Cutaneous 73 mL/100mL Spray Topical 70 mL/100mL Liquid Topical 0.50 mL/1mL Liquid Topical 924 mg/1mL Solution Topical 462 mg/1mL Cloth Topical 2.97 g/1 Gel Topical 75.8 mL/100mL Liquid Topical .91 mg/1mL Liquid Topical .91 L/100L Liquid Topical 0.70 mg/1mL Liquid Topical 0.91 mg/1mL Liquid Topical 175 mL/350mL Liquid Topical 350 mL/500mL Liquid Topical 613 mg/1mL Liquid Topical 700 mL/1L Liquid Topical 91 mg/1mL Solution Topical 0.105 mL/0.15mL Solution Topical 30 mg/1mL Solution Topical 75 mL/60mL Solution Topical 750 g/1kg Solution Topical 91 mL/100mL Spray Topical 550.2 g/1L Spray Topical 700 mL/1L Swab Topical .7 mL/1 Swab Topical 0.75 g/1 Cloth Topical 7.5 mL/1 Liquid Topical 0.91 mL/1mL Liquid Topical 990 mg/100mL Liquid Topical 990 mg/1mL Soap Topical 75 mL/100mL Solution Topical 37.88 mL/50mL Spray Topical 750 mL/1L Cloth Topical 700 mg/1g Liquid Topical 75 L/100L Liquid Topical 99 % Solution Topical .70 mL/1mL Sponge Topical 0.07 mL/1mL Liquid Topical 0.7 mL/1mL Liquid Topical .7 mL/1mL Cloth Extracorporeal Cloth Topical 2.8 mL/1 Cloth Topical 3.75 mL/1 Cloth Topical 4.2 mL/1 Solution Topical 50 mL/100mL Liquid Cutaneous 350 mL/500mL Solution Topical 0.7 L/1L Solution Topical 700 mg/1mL Gel Topical 99 mL/100mL Liquid Topical 30 mg/1mL Liquid Topical 700 mg/100mL Liquid Extracorporeal 187.5 mL/250mL Solution Topical 0.7 mL/1mL Solution Topical 90 mL/100mL Liquid Topical 99 mL/100mL Swab Topical 70 mL/100mL Gel Topical 65 mL/100mL Cloth Cutaneous; Topical Swab Cutaneous; Topical 70 mL/100mL Cloth Topical 0.25 g/1 Spray Topical 75 mL/100mL Spray Topical 1 mL/1mL Cloth; cream; gel; kit; ointment; solution Ophthalmic; Topical Kit Ophthalmic Solution Topical 700 g/1L Spray Topical 15 g/100g Injection, solution; kit Subcutaneous; Topical Kit Subcutaneous Kit Subcutaneous; Topical Injection; kit Parenteral; Topical Liquid Topical 65 mL/100mL Injection, solution; kit; solution Intravenous; Topical Gel Cutaneous Liquid Topical Kit Epidural; Infiltration; Intra-articular; Intramuscular; Topical Injection, powder, lyophilized, for suspension; kit; tablet Intramuscular; Oral; Topical Injection, powder, lyophilized, for suspension; kit Intramuscular; Topical Spray Topical 95.07 mL/100mL Salve Topical 0.25 mL/120mL Liquid Topical 10 g/100g Kit Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Topical Swab Topical 0.70 mL/1mL Spray Topical 44.69 mL/59mL Cloth Topical 70 mL/100mL Cloth Topical 0.7 mL/1 Cloth Topical 0.7 g/1 Gel Topical 56.8 mL/71mL Injection, solution; injection, suspension; kit; solution; swab Epidural; Infiltration; Intra-articular; Intramuscular; Intrathecal; Intravascular; Intravenous; Perineural; Topical Liquid Topical 630 mg/1g Liquid Topical 700 mL/1000mL Kit Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical Liquid Topical 97.79 % Solution / drops Auricular (otic) 950 mg/1mL Liquid Topical 71 mL/100mL Injection, solution; kit Epidural; Intracaudal; Intramuscular; Intravenous; Perineural; Topical Aerosol, spray Topical Liquid Extracorporeal; Topical 75 mL/100mL Swab Topical 0.8 g/1 Swab Topical 1.59 g/1 Liquid Topical 75.17 mL/100mL Gel Topical 7.5 mL/1 Gel Topical 74 mL/100mL Solution Auricular (otic) 0.95 g/1mL Injection, solution; injection, suspension; kit Infiltration; Intra-articular; Intramuscular; Perineural; Topical Stick Topical 70 % Liquid Topical 88.5 mL/118mL Injection, solution; kit; solution Epidural; Infiltration; Intracaudal; Intravenous; Perineural; Topical Injection, suspension; kit; solution Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical Injection, solution; injection, suspension; kit; solution Epidural; Infiltration; Intra-articular; Intracaudal; Intralesional; Intramuscular; Intravenous; Perineural; Soft tissue; Topical Injection, suspension; kit; solution Intra-articular; Intramuscular; Topical Injection, solution; injection, suspension; kit; solution Epidural; Infiltration; Intra-articular; Intracaudal; Intramuscular; Intravenous; Perineural; Topical Injection; injection, solution; kit; solution Epidural; Intracaudal; Intravenous; Perineural; Topical Injection, solution; kit; solution Epidural; Intracaudal; Intravenous; Perineural; Topical Solution Topical 77.6 L/100L Liquid Topical 1 mL/1 Kit Intramuscular; Subcutaneous; Topical Kit Infiltration; Soft tissue; Topical Kit Epidural; Infiltration; Intracaudal; Perineural Kit Epidural; Infiltration; Intracaudal Liquid Topical 2.846 L/3.785L Solution Topical 2.839 L/3.785L Swab Topical 700 mg/1mL Liquid Topical 75 mL/100mL Cloth Topical 0.75 1/1 Cloth Topical 75 1/1001 Solution Topical 305.9 mL/437mL Gel Topical 49 % Gel Topical Cloth Topical 75 mL/1001 Gel Topical 70 g/100g Sponge Topical Spray Topical 42 g/56g Cloth; kit; spray Topical Spray Topical 21.1 mL/30mL Liquid Topical 0.45 mg/1g Solution Topical 99 mL/100mL Cloth Cutaneous; Topical 72.5 mg/100mg Swab Topical 0.7 mL/1g Solution Topical 75 mL/100mL Liquid Topical 75 mL/75mL Gel Topical 72 mg/100mL Spray Topical 72 mg/100mL Liquid Topical 72 L/100L Cloth Topical 75 mL/100g Cloth Topical 0.7 U/1U Gel Topical 750 L/1000L Liquid Topical 750 L/1000L Solution / drops Topical 75 mL/100mL Liquid Nasal 70 mL/100g Gel Topical 75 mL/75mL Cloth Topical 150 mL/501 Gel Topical 0.72 L/1L Cloth Topical 1 mL/1 Cloth Topical 75 g/100g Cloth Topical 70 mL/1001 Cloth Topical 0.75 mL/1g Cloth Topical 3 mL/1 Liquid Topical 0.7515 mL/1mL Solution Topical 1.75 mL/25mL Soap Topical Gel Topical 700 g/1kg Liquid Topical 20 mL/29mL Liquid Topical 250 mL/354mL Liquid Topical 2650 mL/3785mL Liquid Topical 41 mL/59mL Liquid Topical 669 mL/946mL Cloth Topical 0.75 mL/1mL Solution Topical 70 L/100L Gel Topical 700 mL/1L Cloth Topical 0.7 mL/1mL Cream Topical 70 mL/100mL Solution; sponge Topical Liquid Extracorporeal 180 mL/240mL Liquid Extracorporeal 225 mL/300mL Liquid Extracorporeal 37.5 mL/50mL Liquid Extracorporeal 375 mL/500mL Liquid Extracorporeal 3750 mL/5000mL Liquid Extracorporeal 45 mL/60mL Liquid Extracorporeal 75 mL/100mL Liquid Extracorporeal 750 mL/1000mL Liquid Extracorporeal 90 mL/120mL Solution Topical 75 L/100mL Patch Topical 0.7 mL/1mL Liquid Topical 0.8 g/1mL Solution Solution Topical Liquid Topical 70 L/100L Liquid Topical 95 mL / 100 mL Gel Topical 63 g Stick Topical 70 1/1001 Solution Auricular (otic) 950 mg/1mL Injection, solution; kit Intramuscular; Topical Lotion Topical 70 mL/100mL Kit Topical Liquid Topical 70.14 g/100mL Solution Topical 0.13 g/1mL Kit Intravenous; Topical Liquid Topical 0.7 mL/0.7mL Cloth Extracorporeal 75 mL/100mL Liquid Topical 99.9 mL/100mL Gel Topical 17.4585 g/29.6mL Liquid Topical 90 mL/100mL Cloth Topical Solution Topical 165.9 mL/237mL Solution Topical 1.155 mL/1 Gel Topical 65 % Cloth Topical 80.0852 L/100L Solution Topical 336 mL/480mL Gel Topical 74 L/100L Solution Topical 0.28 mL/1 Liquid Topical 63 mL/100mL Liquid Topical 0.7 mL/1 Sponge Topical .7 mL/.7mL Sponge Topical .7 1/.7mL Kit; patch; swab Topical Cloth Topical 55 1/1001 Sponge Topical 0.7 mL/0.7mL Solution 77.77 ml/100ml Solution 70 ml/100ml - Prices
- Not Available
- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region US6036976 No 2000-03-14 2016-12-13 US US7422388 No 2008-09-09 2027-04-25 US US6536975 No 2003-03-25 2020-11-10 US US6729786 No 2004-05-04 2023-03-14 US US7241065 No 2007-07-10 2023-03-14 US US5690958 No 1997-11-25 2016-09-30 US US6991394 No 2006-01-31 2024-01-31 US US7182536 No 2007-02-27 2023-12-30 US US5538353 No 1996-07-23 2015-08-25 US US5772346 No 1998-06-30 2017-04-22 US USD468424 No 2003-01-07 2017-01-07 US US9295657 No 2016-03-29 2035-03-13 US US9119876 No 2015-09-01 2035-03-13 US US8623935 No 2014-01-07 2029-07-26 US US9629368 No 2017-04-25 2028-05-23 US US9844654 No 2017-12-19 2036-04-24 US US10688291 No 2020-06-23 2034-12-20 US US8389583 No 2013-03-05 2029-08-09 US US8703828 No 2014-04-22 2028-05-23 US US8226971 No 2012-07-24 2025-05-06 US US9011897 No 2015-04-21 2025-02-08 US
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) -89.5 °C PhysProp boiling point (°C) 82.3 °C PhysProp water solubility 1E+006 mg/L (at 25 °C) RIDDICK,JA ET AL. (1986) logP 0.05 HANSCH,C ET AL. (1995) pKa 17.1 SERJEANT,EP & DEMPSEY,B (1979) - Predicted Properties
Property Value Source Water Solubility 378.0 mg/mL ALOGPS logP 0.04 ALOGPS logP 0.25 Chemaxon logS 0.8 ALOGPS pKa (Strongest Acidic) 17.26 Chemaxon pKa (Strongest Basic) -1.8 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 20.23 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 17.43 m3·mol-1 Chemaxon Polarizability 7.14 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9905 Blood Brain Barrier + 0.9694 Caco-2 permeable + 0.7135 P-glycoprotein substrate Non-substrate 0.8146 P-glycoprotein inhibitor I Non-inhibitor 0.9609 P-glycoprotein inhibitor II Non-inhibitor 0.9785 Renal organic cation transporter Non-inhibitor 0.932 CYP450 2C9 substrate Non-substrate 0.8061 CYP450 2D6 substrate Non-substrate 0.8916 CYP450 3A4 substrate Non-substrate 0.7103 CYP450 1A2 substrate Non-inhibitor 0.8634 CYP450 2C9 inhibitor Non-inhibitor 0.9466 CYP450 2D6 inhibitor Non-inhibitor 0.9581 CYP450 2C19 inhibitor Non-inhibitor 0.9267 CYP450 3A4 inhibitor Non-inhibitor 0.9764 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.949 Ames test Non AMES toxic 0.9246 Carcinogenicity Carcinogens 0.7397 Biodegradation Ready biodegradable 0.7608 Rat acute toxicity 1.3372 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9583 hERG inhibition (predictor II) Non-inhibitor 0.9457
Spectra
- Mass Spec (NIST)
- Download (3.84 KB)
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 98.2168216 predictedDarkChem Lite v0.1.0 [M-H]- 98.2450216 predictedDarkChem Lite v0.1.0 [M-H]- 98.1942216 predictedDarkChem Lite v0.1.0 [M-H]- 98.2359216 predictedDarkChem Lite v0.1.0 [M-H]- 120.13784 predictedDeepCCS 1.0 (2019) [M+H]+ 99.0474216 predictedDarkChem Lite v0.1.0 [M+H]+ 99.2250216 predictedDarkChem Lite v0.1.0 [M+H]+ 99.0675216 predictedDarkChem Lite v0.1.0 [M+H]+ 99.2683216 predictedDarkChem Lite v0.1.0 [M+H]+ 122.03325 predictedDeepCCS 1.0 (2019) [M+Na]+ 98.3364216 predictedDarkChem Lite v0.1.0 [M+Na]+ 98.3669216 predictedDarkChem Lite v0.1.0 [M+Na]+ 98.4543216 predictedDarkChem Lite v0.1.0 [M+Na]+ 130.1671 predictedDeepCCS 1.0 (2019)
Targets
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway (PubMed:1378832). NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets
- Specific Function
- actin monomer binding
- Gene Name
- NOS3
- Uniprot ID
- P29474
- Uniprot Name
- Nitric oxide synthase 3
- Molecular Weight
- 133273.59 Da
References
- Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F: TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957)
- Specific Function
- apolipoprotein A-I receptor binding
- Gene Name
- NR1H2
- Uniprot ID
- P55055
- Uniprot Name
- Oxysterols receptor LXR-beta
- Molecular Weight
- 50973.375 Da
References
- Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F: TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:11121422, PubMed:19556236, PubMed:7703255). Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (PubMed:20055707)
- Specific Function
- enzyme binding
- Gene Name
- HMOX1
- Uniprot ID
- P09601
- Uniprot Name
- Heme oxygenase 1
- Molecular Weight
- 32818.345 Da
References
- Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F: TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown
- Specific Function
- calcium ion binding
- Gene Name
- GCH1
- Uniprot ID
- P30793
- Uniprot Name
- GTP cyclohydrolase 1
- Molecular Weight
- 27902.855 Da
References
- Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F: TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids with implications in host antimicrobial defense, inflammatory response and tissue regeneration (PubMed:10455175, PubMed:10681567, PubMed:2925633). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:10455175, PubMed:10681567). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:10358193, PubMed:11694541). Upon sterile inflammation, targets membrane phospholipids of extracellular mitochondria released from activated platelets, generating free unsaturated fatty acids such as arachidonate that is used by neighboring leukocytes to synthesize inflammatory eicosanoids such as leukotrienes. Simultaneously, by compromising mitochondrial membrane integrity, promotes the release in circulation of potent damage-associated molecular pattern molecules that activate the innate immune response (PubMed:25082876). Plays a stem cell regulator role in the intestinal crypt. Within intracellular compartment mediates Paneth cell differentiation and its stem cell supporting functions by inhibiting Wnt signaling pathway in intestinal stem cell (ICS). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ICS cells and tissue regeneration (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (PubMed:14998370). Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 (PubMed:18635536, PubMed:25398877). Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:25398877). Induces cell proliferation in an integrin-dependent manner (PubMed:18635536)
- Specific Function
- calcium ion binding
- Gene Name
- PLA2G2A
- Uniprot ID
- P14555
- Uniprot Name
- Phospholipase A2, membrane associated
- Molecular Weight
- 16082.525 Da
References
- Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F: TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:16829952, PubMed:22517918, PubMed:23396208). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (PubMed:12794819). Promotes osteoclastogenesis and therefore mediates bone resorption (By similarity)
- Specific Function
- cytokine activity
- Gene Name
- TNF
- Uniprot ID
- P01375
- Uniprot Name
- Tumor necrosis factor
- Molecular Weight
- 25644.15 Da
References
- Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F: TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751. [Article]
Drug created at June 13, 2005 13:24 / Updated at October 07, 2024 17:35