Aminopeptidase N

BE0001078ProteinHumansANPEP

Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. It is acted on by 6 drugs in DrugBank.

Gene name
ANPEP
UniProtKB entry
P15144Swiss-Prot
Cellular location
Cell membrane
Residues / weight
967 residues · 109,539 Da
Also known as
3.4.11.2 · Alanyl aminopeptidase · Aminopeptidase M · AP-M · AP-N

Resolves to

Protein
UniProtP15144UniProt nameAMPN_HUMAN
Gene
HGNCHGNC:500NCBI Gene290GenBank28678GeneCardsANPEP
Pharmacology
IUPHAR/GtoPdb1560KEGGhsa:290
Structure
PDB4FYQPDB4FYRPDB4FYS
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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4GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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38+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aminopeptidase N, how selective are they, and which programs against it are still in active trials?

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