Cyclin-dependent kinase 1

BE0001082ProteinHumansCDK1

Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527,... It is acted on by 28 drugs in DrugBank.

Gene name
CDK1
UniProtKB entry
P06493Swiss-Prot
Cellular location
Nucleus
Residues / weight
297 residues · 34,095 Da
Also known as
2.7.11.22 · 2.7.11.23 · CDC2 · CDC28A · CDK1

Resolves to

Protein
UniProtP06493UniProt nameCDK1_HUMAN
Gene
HGNCHGNC:1722NCBI Gene983GenBank29839GeneCardsCDK1
Pharmacology
IUPHAR/GtoPdb1961KEGGhsa:983
Structure
PDB4Y72PDB4YC3PDB4YC6
Drugs

What you can answer from here — as of September 07, 2019

28DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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32GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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105+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cyclin-dependent kinase 1, how selective are they, and which programs against it are still in active trials?

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