Intercellular adhesion molecule 1

BE0001085ProteinHumansICAM1

Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the... It is acted on by 9 drugs in DrugBank.

Gene name
ICAM1
UniProtKB entry
P05362Swiss-Prot
Cellular location
Cell membrane
Residues / weight
532 residues · 57,825 Da
Also known as
ICAM-1 · Major group rhinovirus receptor

Resolves to

Protein
UniProtP05362UniProt nameICAM1_HUMAN
Gene
HGNCHGNC:5344NCBI Gene3383GenBank758074GeneCardsICAM1
Pharmacology
KEGGhsa:3383
Structure
PDB1D3EPDB1D3IPDB1D3L
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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13Clinical trialsTrials of drugs acting on it, by phase and status
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23GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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47+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Intercellular adhesion molecule 1, how selective are they, and which programs against it are still in active trials?

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