Tissue-type plasminogen activator

BE0001088ProteinHumansPLAT

Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. It is acted on by 17 drugs in DrugBank.

Gene name
PLAT
UniProtKB entry
P00750Swiss-Prot
Cellular location
Secreted, extracellular space
Residues / weight
562 residues · 62,916 Da
Also known as
3.4.21.68 · t-PA · t-plasminogen activator · tPA

Resolves to

Protein
UniProtP00750UniProt nameTPA_HUMAN
Gene
HGNCHGNC:9051NCBI Gene5327GenBank339834GeneCardsPLAT
Pharmacology
IUPHAR/GtoPdb2392KEGGhsa:5327
Structure
PDB1A5HPDB1BDAPDB1PK2
Drugs

What you can answer from here — as of September 07, 2019

17DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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9GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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62+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tissue-type plasminogen activator, how selective are they, and which programs against it are still in active trials?

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