Aminacrine
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Aminacrine is a slow-acting germicide effective against bacteria and fungi which is included in drug formulations for its anti-septic properties.
- Generic Name
- Aminacrine
- DrugBank Accession Number
- DB11561
- Background
A highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH indicator.
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 194.237
Monoisotopic: 194.08439833 - Chemical Formula
- C13H10N2
- Synonyms
- 10-amino-5-azaanthracene
- 5-aminoacridine
- 9-acridinamine
- 9AA
- Aminacrin
- Aminacrine
- Aminoacridina
- Aminoacridine
- Aminoacridinum
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Symptomatic treatment of Pain ••• ••• ••• Symptomatic treatment of Pain ••• ••• ••• Used in combination for prophylaxis of Skin infections Combination Product in combination with: Cetrimonium (DB01718) ••• ••• ••••• Used in combination for prophylaxis of Skin infections Combination Product in combination with: Cetrimonium (DB01718) ••• ••• ••••• Used in combination for prophylaxis of Skin infections Combination Product in combination with: Cetrimonium (DB01718) ••• ••• ••••• - Contraindications & Blackbox Warnings
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Aminacrine hydrochloride OR5RM3Q5QL 134-50-9 FTGPOQQGJVJDCT-UHFFFAOYSA-N - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image MEDIJEL GEL Aminacrine hydrochloride (0.05 % w/w) + Lidocaine hydrochloride (0.66 % w/w) Gel Submucosal INDRUGCO PTE LTD 1990-06-22 Not applicable Singapore
Categories
- ATC Codes
- D08AA02 — Aminoacridine
- Drug Categories
- Acridine Derivatives
- Acridines
- Aminoacridines
- Anti-Infective Agents
- Anti-Infective Agents, Local
- Antiseptics and Disinfectants
- Coloring Agents
- Compounds used in a research, industrial, or household setting
- Dermatologicals
- Fluorescent Dyes
- Heterocyclic Compounds, Fused-Ring
- Indicators and Reagents
- Laboratory Chemicals
- Luminescent Agents
- Mutagens
- Noxae
- Toxic Actions
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as acridines. These are organic compounds containing the acridine moiety, a linear tricyclic heterocycle which consists of two benzene rings joined by a pyridine ring.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Quinolines and derivatives
- Sub Class
- Benzoquinolines
- Direct Parent
- Acridines
- Alternative Parents
- 4-aminoquinolines / Aminopyridines and derivatives / Benzenoids / Heteroaromatic compounds / Azacyclic compounds / Primary amines / Organopnictogen compounds / Hydrocarbon derivatives
- Substituents
- 4-aminoquinoline / Acridine / Amine / Aminopyridine / Aminoquinoline / Aromatic heteropolycyclic compound / Azacycle / Benzenoid / Heteroaromatic compound / Hydrocarbon derivative
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- aminoacridines, primary amino compound (CHEBI:74789)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 78OY3Z0P7Z
- CAS number
- 90-45-9
- InChI Key
- XJGFWWJLMVZSIG-UHFFFAOYSA-N
- InChI
- InChI=1S/C13H10N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H,(H2,14,15)
- IUPAC Name
- acridin-9-amine
- SMILES
- NC1=C2C=CC=CC2=NC2=C1C=CC=C2
References
- General References
- Manivannan C, Sundaram KM, Renganathan R, Sundararaman M: Investigations on photoinduced interaction of 9-aminoacridine with certain catechols and rutin. J Fluoresc. 2012 Jul;22(4):1113-25. doi: 10.1007/s10895-012-1050-4. Epub 2012 Apr 3. [Article]
- Turhan K, Ozturkcan SA, Turgut Z, Karadayi M, Gulluce M: Inhibition of the mutagenic effects of N-methyl-N'-nitro-N-nitrosoguanidine and 9-aminoacridine by indenopyridines in the Salmonella typhimurium tester strain 1537 and E. coli. Drug Chem Toxicol. 2014 Oct;37(4):365-9. doi: 10.3109/01480545.2013.866136. Epub 2013 Dec 16. [Article]
- Manivannan C, Vijay Solomon R, Venuvanalingam P, Renganathan R: Studies on the inclusion behavior of 9-Aminoacridine into cyclodextrins: spectroscopic and theoretical evidences. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Feb 15;103:18-24. doi: 10.1016/j.saa.2012.11.014. Epub 2012 Nov 16. [Article]
- EMC Summary of Product Characteristics: Medijel (lidocaine hydrochloride/aminoacridine hydrochloride) oral gel [Link]
- External Links
- PubChem Compound
- 7019
- PubChem Substance
- 347827984
- ChemSpider
- 6752
- BindingDB
- 72700
- 645
- ChEBI
- 74789
- ChEMBL
- CHEMBL43184
- ZINC
- ZINC000019014768
- Wikipedia
- 9-Aminoacridine
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Gel Oral; Topical Gel Submucosal 0.05 % w/w - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0755 mg/mL ALOGPS logP 2.75 ALOGPS logP 2.68 Chemaxon logS -3.4 ALOGPS pKa (Strongest Basic) 9.29 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 38.91 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 60.76 m3·mol-1 Chemaxon Polarizability 21.31 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS splash10-0006-0900000000-f3177a69b083c1f124d7 Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-0002-0900000000-7cbf1e2160e83878ec45 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0006-0900000000-fc08e97677904e6db18f Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-0002-0900000000-7cbf1e2160e83878ec45 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0006-0900000000-e89b4469a8778f1396ef Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-00kb-0900000000-5138f996348deb96deb7 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-0006-0900000000-a54f26b82e769c177701 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 145.7559523 predictedDarkChem Lite v0.1.0 [M-H]- 137.14853 predictedDeepCCS 1.0 (2019) [M+H]+ 145.4232523 predictedDarkChem Lite v0.1.0 [M+H]+ 139.54408 predictedDeepCCS 1.0 (2019) [M+Na]+ 146.0857523 predictedDarkChem Lite v0.1.0 [M+Na]+ 146.4868 predictedDeepCCS 1.0 (2019)
Drug created at March 23, 2016 23:35 / Updated at May 05, 2021 20:31