Kallikrein-1

BE0001091ProteinHumansKLK1

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. It is acted on by 8 drugs in DrugBank.

Gene name
KLK1
UniProtKB entry
P06870Swiss-Prot
Residues / weight
262 residues · 28,889 Da
Also known as
3.4.21.35 · Kidney/pancreas/salivary gland kallikrein · Tissue kallikrein

Resolves to

Protein
UniProtP06870UniProt nameKLK1_HUMAN
Gene
HGNCHGNC:6357NCBI Gene3816GenBank186653GeneCardsKLK1
Pharmacology
IUPHAR/GtoPdb2865KEGGhsa:3816
Structure
PDB1SPJPDB8YGY
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Kallikrein-1, how selective are they, and which programs against it are still in active trials?

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