Kallikrein-1
Details
- Name
- Kallikrein-1
- Kind
- protein
- Synonyms
- 3.4.21.35
- Kidney/pancreas/salivary gland kallikrein
- Tissue kallikrein
- Gene Name
- KLK1
- UniProtKB Entry
- P06870Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0037122|Kallikrein-1 MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK PSVAVRVLSYVKWIEDTIAENS
- Number of residues
- 262
- Molecular Weight
- 28889.425
- Theoretical pI
- 4.39
- GO Classification
- Not Available
- General Function
- Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin
- Specific Function
- serine-type endopeptidase activity
- Pfam Domain Function
- Trypsin (PF00089)
- Signal Regions
- 1-18
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0010764|Kallikrein-1 (KLK1) ATGTGGTTCCTGGTTCTGTGCCTCGCCCTGTCCCTGGGGGGGACTGGTGCTGCGCCCCCG ATTCAGTCCCGGATTGTGGGAGGCTGGGAGTGTGAGCAGCATTCCCAGCCCTGGCAGGCG GCTCTGTACCATTTCAGCACTTTCCAGTGTGGGGGCATCCTGGTGCACCGCCAGTGGGTG CTCACAGCTGCTCATTGCATCAGCGACAATTACCAGCTCTGGCTGGGTCGCCACAACTTG TTTGACGACGAAAACACAGCCCAGTTTGTTCATGTCAGTGAGAGCTTCCCACACCCTGGC TTCAACATGAGCCTCCTGGAGAACCACACCCGCCAAGCAGACGAGGACTACAGCCACGAC CTCATGCTGCTCCGCCTGACAGAGCCTGCTGATACCATCACAGATGCTGTGAAGGTCGTG GAGTTGCCCACCGAGGAACCCGAAGTGGGGAGCACCTGTTTGGCTTCCGGCTGGGGCAGC ATCGAACCAGAGAATTTCTCATTTCCAGATGATCTCCAGTGTGTGGACCTCAAAATCCTG CCTAATGATGAGTGCAAAAAAGCCCACGTCCAGAAGGTGACAGACTTCATGCTGTGTGTC GGACACCTGGAAGGTGGCAAAGACACCTGTGTGGGTGATTCAGGGGGCCCGCTGATGTGT GATGGTGTGCTCCAAGGTGTCACATCATGGGGCTACGTCCCTTGTGGCACCCCCAATAAG CCTTCTGTCGCCGTCAGAGTGCTGTCTTATGTGAAGTGGATCGAGGACACCATAGCGGAG AACTCCTGA
- Chromosome Location
- 19
- Locus
- 19q13.33
- External Identifiers
Resource Link UniProtKB ID P06870 UniProtKB Entry Name KLK1_HUMAN GenBank Protein ID 186653 GenBank Gene ID M25629 GeneCard ID KLK1 GenAtlas ID KLK1 HGNC ID HGNC:6357 PDB ID(s) 1SPJ, 8YGY KEGG ID hsa:3816 IUPHAR/Guide To Pharmacology ID 2865 NCBI Gene ID 3816 - General References
- Fukushima D, Kitamura N, Nakanishi S: Nucleotide sequence of cloned cDNA for human pancreatic kallikrein. Biochemistry. 1985 Dec 31;24(27):8037-43. [Article]
- Evans BA, Yun ZX, Close JA, Tregear GW, Kitamura N, Nakanishi S, Callen DF, Baker E, Hyland VJ, Sutherland GR, et al.: Structure and chromosomal localization of the human renal kallikrein gene. Biochemistry. 1988 May 3;27(9):3124-9. [Article]
- Angermann A, Bergmann C, Appelhans H: Cloning and expression of human salivary-gland kallikrein in Escherichia coli. Biochem J. 1989 Sep 15;262(3):787-93. [Article]
- Chen LM, Murray SR, Chai KX, Chao L, Chao J: Molecular cloning and characterization of a novel kallikrein transcript in colon and its distribution in human tissues. Braz J Med Biol Res. 1994 Aug;27(8):1829-38. [Article]
- Yousef GM, Chang A, Scorilas A, Diamandis EP: Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4. Biochem Biophys Res Commun. 2000 Sep 16;276(1):125-33. [Article]
- Gan L, Lee I, Smith R, Argonza-Barrett R, Lei H, McCuaig J, Moss P, Paeper B, Wang K: Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. Gene. 2000 Oct 17;257(1):119-30. [Article]
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- Baker AR, Shine J: Human kidney kallikrein: cDNA cloning and sequence analysis. DNA. 1985 Dec;4(6):445-50. [Article]
- Kellermann J, Lottspeich F, Geiger R, Deutzmann R: Human urinary kallikrein--amino acid sequence and carbohydrate attachment sites. Protein Seq Data Anal. 1988 Feb;1(3):177-82. [Article]
- Lu HS, Lin FK, Chao L, Chao J: Human urinary kallikrein. Complete amino acid sequence and sites of glycosylation. Int J Pept Protein Res. 1989 Apr;33(4):237-49. [Article]
- Lottspeich F, Geiger R, Henschen A, Kutzbach C: N-Terminal amino acid sequence of human urinary kallikrein homology with other serine proteases. Hoppe Seylers Z Physiol Chem. 1979 Dec;360(12):1947-50. [Article]
- Takahashi S, Irie A, Katayama Y, Ito K, Miyake Y: N-terminal amino acid sequence of human urinary prokallikrein. J Biochem. 1986 Mar;99(3):989-92. [Article]
- Laxmikanthan G, Blaber SI, Bernett MJ, Scarisbrick IA, Juliano MA, Blaber M: 1.70 A X-ray structure of human apo kallikrein 1: structural changes upon peptide inhibitor/substrate binding. Proteins. 2005 Mar 1;58(4):802-14. [Article]
- Slim R, Torremocha F, Moreau T, Pizard A, Hunt SC, Vuagnat A, Williams GH, Gauthier F, Jeunemaitre X, Alhenc-Gelas F: Loss-of-function polymorphism of the human kallikrein gene with reduced urinary kallikrein activity. J Am Soc Nephrol. 2002 Apr;13(4):968-76. [Article]
- Azizi M, Boutouyrie P, Bissery A, Agharazii M, Verbeke F, Stern N, Bura-Riviere A, Laurent S, Alhenc-Gelas F, Jeunemaitre X: Arterial and renal consequences of partial genetic deficiency in tissue kallikrein activity in humans. J Clin Invest. 2005 Mar;115(3):780-7. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Lanoteplase investigational unknown target Details Aprotinin approved, investigational, withdrawn yes target Details Nafamostat investigational yes target inhibitor Details Aniline experimental unknown target Details Benzamidine experimental unknown target Details Aluminium approved, investigational unknown target inhibitor Details Aluminium phosphate approved, investigational unknown target Details Aluminum acetate approved, investigational unknown target Details