Aluminium phosphate

Identification

Generic Name
Aluminium phosphate
DrugBank Accession Number
DB14517
Background

Not Available

Type
Small Molecule
Groups
Approved, Investigational
Structure
Thumb
Weight
Average: 121.9529
Monoisotopic: 121.934958441
Chemical Formula
AlO4P
Synonyms
  • Aluminum phosphate

Pharmacology

Indication

Not Available

Pharmacology
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action

Aluminum Acetate is an astringent. An astrignent is a chemical that tends to shrink or constrict body tissues, usually locally after topical medicinal application. The shrinkage or constriction is through osmotic flow of water (or other fluids) away from the area where the astringent was applied. Astringent medicines cause shrinkage of mucous membranes or exposed tissues and are often used internally to check discharge of blood serum or mucous secretions. This can happen with a sore throat, hemorrhages, diarrhea, or with peptic ulcers. Externally applied astringents, which cause mild coagulation of skin proteins, dry, harden, and protect the skin. Acne sufferers are often advised to use astringents if they have oily skin. Astringents also help heal stretch marks and other scars. Mild astringent solutions are used in the relief of such minor skin irritations as those resulting from superficial cuts, allergies, insect bites, or fungal infections such as athlete's foot.

TargetActionsOrganism
USerotransferrinNot AvailableHumans
USodium/potassium-transporting ATPase subunit alpha-1Not AvailableHumans
UKallikrein-1Not AvailableHumans
UAmyloid beta A4 proteinNot AvailableHumans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetaminophenAluminium phosphate can cause a decrease in the absorption of Acetaminophen resulting in a reduced serum concentration and potentially a decrease in efficacy.
AcetophenazineAluminium phosphate can cause a decrease in the absorption of Acetophenazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Alendronic acidThe serum concentration of Alendronic acid can be decreased when it is combined with Aluminium phosphate.
AlimemazineAluminium phosphate can cause a decrease in the absorption of Alimemazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
AllopurinolThe therapeutic efficacy of Allopurinol can be decreased when used in combination with Aluminium phosphate.
AmphetamineThe serum concentration of Amphetamine can be increased when it is combined with Aluminium phosphate.
AmprenavirAluminium phosphate can cause a decrease in the absorption of Amprenavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
AsunaprevirAluminium phosphate can cause a decrease in the absorption of Asunaprevir resulting in a reduced serum concentration and potentially a decrease in efficacy.
AtazanavirAluminium phosphate can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Beclomethasone dipropionateThe bioavailability of Beclomethasone dipropionate can be decreased when combined with Aluminium phosphate.
Interactions
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Food Interactions
No interactions found.

Products

Products
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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
GelfosGel61.9 g/100gOralBoryung Pharmaceutical Co., Ltd2015-04-182016-12-12US flag
Gelfos MGel61.9 g/100gOralBoryung Pharmaceutical Co., Ltd2015-04-182016-12-12US flag
Gelfos MGel61.9 g/100gOralBoryung Pharmaceutical Co., Ltd2016-02-282016-04-11US flag
GelfoseGel61.9 g/100gOralBoryung Pharmaceutical Co., Ltd2015-03-082016-12-12US flag
Gelfose MGel61.9 g/100gOralBoryung Pharmaceutical Co., Ltd2015-03-082016-12-12US flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Gelfos MAluminium phosphate (61.9 g/100g) + Dimethicone (0.2 g/100g) + Magnesium hydroxide (2 g/100g)GelOralBoryung Pharmaceutical Co., Ltd2016-02-282016-12-12US flag
Gelfos MAluminium phosphate (12.38 g/20g) + Dimethicone (0.04 g/20g) + Magnesium hydroxide (0.4 g/20g)GelOralBoryung Pharmaceutical Co., Ltd.2017-01-012016-12-12US flag
Gelfos MAluminium phosphate (12.38 g/20g) + Dimethicone (0.04 g/20g) + Magnesium hydroxide (0.4 g/20g)SuspensionOralBoryung Pharmaceutical Co., Ltd.2017-01-012017-04-03US flag
Gelfos-MAluminium phosphate (12.38 g/20g) + Dimethicone (40 mg/20g) + Magnesium hydroxide (400 mg/20g)LiquidOralOASIS TRADING2018-11-15Not applicableUS flag
Gelfos-MAluminium phosphate (12.38 g/20g) + Dimethicone (40 mg/20g) + Magnesium hydroxide (400 mg/20g)LiquidOralI World Pharmaceutical Co., Ltd.2019-10-08Not applicableUS flag
Gelfos-MAluminium phosphate (12.38 g/20g) + Dimethicone (40 mg/20g) + Magnesium hydroxide (400 mg/20g)LiquidOralLYDIA Co., Ltd2019-10-08Not applicableUS flag
PRIMPERAN GELAluminium phosphate (4.5 g) + Metoclopramide hydrochloride (0.07 g) + Simethicone (0.25 g)SuspensionOral2008-01-212021-07-01Colombia flag

Categories

ATC Codes
A02AB03 — Aluminium phosphate
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as post-transition metal phosphates. These are inorganic compounds in which the largest oxoanion is phosphate, and in which the heaviest atom not in an oxoanion is a post-transition metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Post-transition metal oxoanionic compounds
Sub Class
Post-transition metal phosphates
Direct Parent
Post-transition metal phosphates
Alternative Parents
Post-transition metal salts / Inorganic salts / Inorganic oxides
Substituents
Inorganic oxide / Inorganic post-transition metal salt / Inorganic salt / Post-transition metal phosphate
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
F92V3S521O
CAS number
7784-30-7
InChI Key
ILRRQNADMUWWFW-UHFFFAOYSA-K
InChI
InChI=1S/Al.H3O4P/c;1-5(2,3)4/h;(H3,1,2,3,4)/q+3;/p-3
IUPAC Name
aluminium(3+) phosphate
SMILES
[Al+3].[O-]P([O-])([O-])=O

References

General References
Not Available
ChemSpider
58204
ChEMBL
CHEMBL3833315
Wikipedia
Aluminium_phosphate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedPreventionDiphtheria / Pertussis / Tetanus1
3CompletedPreventionHaemophilus Influenzae Type b (Hib) Infection1
3CompletedPreventionImmunizations1
2CompletedPreventionEnterovirus 71 Human1
2CompletedPreventionMeningococcal Disease1
2CompletedPreventionRespiratory Syncytial Virus (RSV)1
1CompletedPreventionCytomegalovirus (CMV) Infection1
1CompletedPreventionPlasmodium Falciparum Malaria1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
GelOral
GelOral
SuspensionOral
LiquidOral
GelOral61.9 g/100g
Injection, suspensionIntramuscular
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-1ChemAxon
pKa (Strongest Acidic)1.8ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area86.25 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity11.29 m3·mol-1ChemAxon
Polarizability4.93 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Targets

Drugtargets
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Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Transferrin receptor binding
Specific Function
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from si...
Gene Name
TF
Uniprot ID
P02787
Uniprot Name
Serotransferrin
Molecular Weight
77063.195 Da
References
  1. Nolte E, Beck E, Winklhofer C, Steinhausen C: Compartmental model for aluminium biokinetics. Hum Exp Toxicol. 2001 Feb;20(2):111-7. [PubMed:11327511]
  2. Nagaoka MH, Maitani T: Binding affinity of aluminium to human serum transferrin and effects of carbohydrate chain modification as studied by HPLC/high-resolution ICP-MS--speciation of aluminium in human serum. J Inorg Biochem. 2005 Sep;99(9):1887-94. [PubMed:16139893]
  3. Mizutani K, Mikami B, Aibara S, Hirose M: Structure of aluminium-bound ovotransferrin at 2.15 Angstroms resolution. Acta Crystallogr D Biol Crystallogr. 2005 Dec;61(Pt 12):1636-42. Epub 2005 Nov 19. [PubMed:16301797]
  4. Beardmore J, Rugg G, Exley C: A systems biology approach to the blood-aluminium problem: the application and testing of a computational model. J Inorg Biochem. 2007 Sep;101(9):1187-91. Epub 2007 Jun 12. [PubMed:17629565]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Steroid hormone binding
Specific Function
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates th...
Gene Name
ATP1A1
Uniprot ID
P05023
Uniprot Name
Sodium/potassium-transporting ATPase subunit alpha-1
Molecular Weight
112895.01 Da
References
  1. Menz RI, Walker JE, Leslie AG: Structure of bovine mitochondrial F(1)-ATPase with nucleotide bound to all three catalytic sites: implications for the mechanism of rotary catalysis. Cell. 2001 Aug 10;106(3):331-41. [PubMed:11509182]
  2. Silva VS, Goncalves PP: The inhibitory effect of aluminium on the (Na+/K+)ATPase activity of rat brain cortex synaptosomes. J Inorg Biochem. 2003 Sep 15;97(1):143-50. [PubMed:14507470]
  3. Amador FC, Santos MS, Oliveira CR: Lipid peroxidation and aluminium effects on the cholinergic system in nerve terminals. Neurotox Res. 2001 Jul;3(3):223-33. [PubMed:15111247]
  4. Kohila T, Parkkonen E, Tahti H: Evaluation of the effects of aluminium, ethanol and their combination on rat brain synaptosomal integral proteins in vitro and after 90-day oral exposure. Arch Toxicol. 2004 May;78(5):276-82. [PubMed:15254985]
  5. Kohila T, Tahti H: Effects of aluminium and lead on ATPase activity of knockout +/- mouse cerebral synaptosomes in vitro. Altern Lab Anim. 2004 Oct;32(4):361-7. [PubMed:15651920]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Serine-type endopeptidase activity
Specific Function
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
Gene Name
KLK1
Uniprot ID
P06870
Uniprot Name
Kallikrein-1
Molecular Weight
28889.425 Da
References
  1. De Sousa MO, Santoro MM, De Souza Figueiredo AF: The effect of cations on the amidase activity of human tissue kallikrein: 1-linear competitive inhibition by sodium, potassium, calcium and magnesium. 2-linear mixed inhibition by aluminium. J Enzyme Inhib Med Chem. 2004 Aug;19(4):317-25. [PubMed:15558947]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Transition metal ion binding
Specific Function
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and tra...
Gene Name
APP
Uniprot ID
P05067
Uniprot Name
Amyloid beta A4 protein
Molecular Weight
86942.715 Da
References
  1. Banks WA, Niehoff ML, Drago D, Zatta P: Aluminum complexing enhances amyloid beta protein penetration of blood-brain barrier. Brain Res. 2006 Oct 20;1116(1):215-21. Epub 2006 Aug 30. [PubMed:16942756]

Carriers

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Toxic substance binding
Specific Function
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
Gene Name
ALB
Uniprot ID
P02768
Uniprot Name
Serum albumin
Molecular Weight
69365.94 Da
References
  1. Zatta P, Dalla Via L, Di Noto V: Binding studies on aluminum(III)-albumin interaction. Arch Biochem Biophys. 2003 Sep 1;417(1):59-64. [PubMed:12921780]

Drug created on July 12, 2018 16:38 / Updated on June 12, 2020 16:53