Prostatic acid phosphatase

BE0001102ProteinHumansACP3

A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins (PubMed:10506173, PubMed:15280042, PubMed:20498373, PubMed:9584846, PubMed:8132635). It is acted on by 6 drugs in DrugBank.

Gene name
ACP3
UniProtKB entry
P15309Swiss-Prot
Cellular location
Secreted
Residues / weight
386 residues · 44,566 Da
Also known as
3.1.3.2 · 5'-NT · 5'-nucleotidase · Acid phosphatase 3 · ACPP

Resolves to

Protein
UniProtP15309UniProt namePPAP_HUMAN
Gene
HGNCHGNC:125NCBI Gene55GenBank189613GeneCardsACP3
Pharmacology
KEGGhsa:55
Structure
PDB1CVIPDB1ND5PDB1ND6
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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35+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Prostatic acid phosphatase, how selective are they, and which programs against it are still in active trials?

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