Ras-related C3 botulinum toxin substrate 1

BE0001109ProteinHumansRAC1

Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. It is acted on by 4 drugs in DrugBank.

Gene name
RAC1
UniProtKB entry
P63000Swiss-Prot
Cellular location
Cell membrane
Residues / weight
192 residues · 21,450 Da
Also known as
3.6.5.2 · Cell migration-inducing gene 5 protein · p21-Rac1 · Ras-like protein TC25 · TC25

Resolves to

Protein
UniProtP63000UniProt nameRAC1_HUMAN
Gene
HGNCHGNC:9801NCBI Gene5879GenBank190824GeneCardsRAC1
Pharmacology
KEGGhsa:5879
Structure
PDB1E96PDB1FOEPDB1G4U
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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39GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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67+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ras-related C3 botulinum toxin substrate 1, how selective are they, and which programs against it are still in active trials?

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