Apolipoprotein E

BE0001119ProteinHumansAPOE

APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids (PubMed:14754908, PubMed:1911868, PubMed:6860692). It is acted on by 9 drugs in DrugBank.

Gene name
APOE
UniProtKB entry
P02649Swiss-Prot
Cellular location
Secreted
Residues / weight
317 residues · 36,154 Da
Also known as
Apo-E

Resolves to

Protein
UniProtP02649UniProt nameAPOE_HUMAN
Gene
HGNCHGNC:613NCBI Gene348GenBank178849GeneCardsAPOE
Pharmacology
KEGGhsa:348
Structure
PDB1B68PDB1BZ4PDB1EA8
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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12Clinical trialsTrials of drugs acting on it, by phase and status
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72GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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50+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Apolipoprotein E, how selective are they, and which programs against it are still in active trials?

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