Epithelial discoidin domain-containing receptor 1

BE0001124ProteinHumansDDR1

Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. It is acted on by 5 drugs in DrugBank.

Gene name
DDR1
UniProtKB entry
Q08345Swiss-Prot
Cellular location
Cell membrane
Residues / weight
913 residues · 101,127 Da
Also known as
2.7.10.1 · CAK · CD167 antigen-like family member A · Cell adhesion kinase · Discoidin receptor tyrosine kinase

Resolves to

Protein
UniProtQ08345UniProt nameDDR1_HUMAN
Gene
HGNCHGNC:2730NCBI Gene780GenBank306475GeneCardsDDR1
Pharmacology
IUPHAR/GtoPdb1843KEGGhsa:780
Structure
PDB3ZOSPDB4AG4PDB4BKJ
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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14GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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44+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Epithelial discoidin domain-containing receptor 1, how selective are they, and which programs against it are still in active trials?

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