Phospholipid hydroperoxide glutathione peroxidase GPX4

BE0001135ProteinHumansGPX4

Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (PubMed:40281343). It is acted on by 3 drugs in DrugBank.

Gene name
GPX4
UniProtKB entry
P36969Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
197 residues · 22,175 Da
Also known as
1.11.1.12 · Glutathione peroxidase 4 · GPx-4 · GSHPx-4 · PHGPx

Resolves to

Protein
UniProtP36969UniProt nameGPX4_HUMAN
Gene
HGNCHGNC:4556NCBI Gene2879GenBank825667GeneCardsGPX4
Pharmacology
IUPHAR/GtoPdb3239KEGGhsa:2879
Structure
PDB2GS3PDB2OBIPDB5H5Q
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phospholipid hydroperoxide glutathione peroxidase GPX4, how selective are they, and which programs against it are still in active trials?

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