Stromal cell-derived factor 1

BE0001150ProteinHumansCXCL12

Chemoattractant active on T-lymphocytes and monocytes but not neutrophils (PubMed:18802065, PubMed:39093700). It is acted on by 5 drugs in DrugBank.

Gene name
CXCL12
UniProtKB entry
P48061Swiss-Prot
Cellular location
Secreted
Residues / weight
93 residues · 10,666 Da
Also known as
C-X-C motif chemokine 12 · hIRH · hSDF-1 · Intercrine reduced in hepatomas · IRH

Resolves to

Protein
UniProtP48061UniProt nameSDF1_HUMAN
Gene
HGNCHGNC:10672NCBI Gene6387GenBank571508GeneCardsCXCL12
Pharmacology
KEGGhsa:6387
Structure
PDB1A15PDB1QG7PDB1SDF
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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22Clinical trialsTrials of drugs acting on it, by phase and status
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31GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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32+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Stromal cell-derived factor 1, how selective are they, and which programs against it are still in active trials?

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