ATP-binding cassette sub-family G member 1

BE0001168ProteinHumansABCG1

Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrolysis of ATP (PubMed:17408620, PubMed:24576892). It is acted on by 3 drugs in DrugBank.

Gene name
ABCG1
UniProtKB entry
P45844Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
678 residues · 75,591 Da
Also known as
7.6.2.- · ABC8 · ATP-binding cassette transporter 8 · White protein homolog · WHT1

Resolves to

Protein
UniProtP45844UniProt nameABCG1_HUMAN
Gene
HGNCHGNC:73NCBI Gene9619GenBank1160186GeneCardsABCG1
Pharmacology
KEGGhsa:9619
Structure
PDB7FDVPDB7OZ1PDB7R8C
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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31GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ATP-binding cassette sub-family G member 1, how selective are they, and which programs against it are still in active trials?

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