Zeta-crystallin

BE0001185ProteinHumansCRYZ

Multifunctional crystallin endowed with unrelated mRNA stabilization and enzymatic oxidoreductase activities (PubMed:17497241, PubMed:20103721). It is acted on by 5 drugs in DrugBank.

Gene name
CRYZ
UniProtKB entry
Q08257Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
329 residues · 35,206 Da
Also known as
NADPH:quinone reductase · Quinone oxidoreductase

Resolves to

Protein
UniProtQ08257UniProt nameQOR_HUMAN
Gene
HGNCHGNC:2419NCBI Gene1429GenBank292415GeneCardsCRYZ
Pharmacology
KEGGhsa:1429
Structure
PDB1YB5
Drugs

What you can answer from here — as of June 05, 2026

5DrugsApproved to experimental, with action, bond type and pharmacological action
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Zeta-crystallin, how selective are they, and which programs against it are still in active trials?

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