Fibroblast growth factor receptor 4

BE0001203ProteinHumansFGFR4

Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose... It is acted on by 15 drugs in DrugBank.

Gene name
FGFR4
UniProtKB entry
P22455Swiss-Prot
Cellular location
Cell membrane
Residues / weight
802 residues · 87,954 Da
Also known as
2.7.10.1 · FGFR-4 · JTK2 · TKF

Resolves to

Protein
UniProtP22455UniProt nameFGFR4_HUMAN
Gene
HGNCHGNC:3691NCBI Gene2264GenBank31372GeneCardsFGFR4
Pharmacology
IUPHAR/GtoPdb1811KEGGhsa:2264
Structure
PDB4QQ5PDB4QQCPDB4QQJ
Drugs

What you can answer from here — as of September 07, 2019

15DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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64+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Fibroblast growth factor receptor 4, how selective are they, and which programs against it are still in active trials?

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