Bifunctional purine biosynthesis protein ATIC

BE0001240ProteinHumansATIC

Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). It is acted on by 8 drugs in DrugBank.

Gene name
ATIC
UniProtKB entry
P31939Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
592 residues · 64,615 Da
Also known as
AICAR transformylase/inosine monophosphate cyclohydrolase · ATIC · PURH

Resolves to

Protein
UniProtP31939UniProt namePUR9_HUMAN
Gene
HGNCHGNC:794NCBI Gene471GenBank1263196GeneCardsATIC
Pharmacology
KEGGhsa:471
Structure
PDB1P4RPDB1PKXPDB1PL0
Drugs

What you can answer from here — as of September 03, 2024

8DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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36+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Bifunctional purine biosynthesis protein ATIC, how selective are they, and which programs against it are still in active trials?

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