AICA ribonucleotide

DB01700InvestigationalSmall molecule

5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) is an intermediate in the generation of inosine monophosphate and analog of adenosine monophosphate (AMP) that is capable of stimulating AMP-dependent protein kinase (AMPK) activity. AICAR has... AICAR has been used clinically to treat and protect against cardiac ischemic injury.

Chemical structure of AICA ribonucleotide
Formula / weight
C9H15N4O8P · 338.2112 g/mol (avg)
Also known as
AICA-ribonucleotide · AICAR

Resolves to

Compound
UNIIF0X88YW0YKCAS3031-94-5ChEMBLCHEMBL483849ChEBI18406PubChem65110KEGGC04677
Structure
InChIKeyNOTGFIUVDGNKRI-UUOKFMHZSA-NSMILESNC(=O)C1=C(N)N(C=N1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O
Targets
P31939ATIC

What you can answer from here — as of September 13, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
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609Drug interactionsStructured to mechanism, not free text
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3+ReferencesStructured and connected to the statements they support
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Which drugs share a target with AICA ribonucleotide, and which of those have an active Phase 3 trial?

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