Endolysin

BE0001248ProteinEnterobacteria phage T4E

Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. It is acted on by 22 drugs in DrugBank.

Gene name
E
UniProtKB entry
P00720Swiss-Prot
Cellular location
Host cytoplasm
Residues / weight
164 residues · 18,691 Da
Also known as
3.2.1.17 · Lysis protein · Lysozyme · Muramidase

Resolves to

Protein
UniProtP00720UniProt nameENLYS_BPT4
Gene
NCBI Gene1258585GenBank15261
Pharmacology
KEGGvg:1258585
Structure
PDB102LPDB103LPDB104L
Drugs

What you can answer from here — as of September 04, 2024

22DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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52+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Endolysin, how selective are they, and which programs against it are still in active trials?

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