Protein-glutamine gamma-glutamyltransferase E

BE0001273ProteinHumansTGM3

Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. It is acted on by 5 drugs in DrugBank.

Gene name
TGM3
UniProtKB entry
Q08188Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
693 residues · 76,631 Da
Also known as
2.3.2.13 · TG(E) · TGase E · TGase-3 · TGE

Resolves to

Protein
UniProtQ08188UniProt nameTGM3_HUMAN
Gene
HGNCHGNC:11779NCBI Gene7053GenBank307504GeneCardsTGM3
Pharmacology
KEGGhsa:7053
Structure
PDB1L9MPDB1L9NPDB1NUD
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protein-glutamine gamma-glutamyltransferase E, how selective are they, and which programs against it are still in active trials?

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