Cruzipain

BE0001292ProteinTrypanosoma cruzi

Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. It is acted on by 15 drugs in DrugBank.

UniProtKB entry
P25779Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
467 residues · 49,836 Da
Also known as
3.4.22.51 · Cruzaine · Major cysteine proteinase

Resolves to

Protein
UniProtP25779UniProt nameCYSP_TRYCR
Gene
GenBank162048
Structure
PDB1AIMPDB1EWLPDB1EWM
Drugs

What you can answer from here — as of September 07, 2019

15DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cruzipain, how selective are they, and which programs against it are still in active trials?

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