Menaquinone 6
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Name
- Menaquinone 6
- Accession Number
- DB14936
- Description
Menaquinone 6 is under investigation in clinical trial NCT01194778 (Comparison of Efficacy of Different Dosages Vitamin K2).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Menaquinone 6 (DB14936)
- Weight
- Average: 580.8821
Monoisotopic: 580.428031036 - Chemical Formula
- C41H56O2
- Synonyms
- VITAMIN K2
Pharmacology
- Indication
- Not Available
- Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
Learn More- Pharmacodynamics
- Not Available
- Mechanism of action
- Not Available
- Absorption
- Not Available
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
- Not Available
- Route of elimination
- Not Available
- Half-life
- Not Available
- Clearance
- Not Available
- Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More- Toxicity
- Not Available
- Affected organisms
- Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Unlock Additional DataOrlistat Orlistat can cause a decrease in the absorption of Menaquinone 6 resulting in a reduced serum concentration and potentially a decrease in efficacy. Additional Data Available- Extended DescriptionExtended Description
Extended description of the mechanism of action and particular properties of each drug interaction.
Learn more - Severity
- Evidence Level
- ActionAction
An effect category for each drug interaction. Know how this interaction affects the subject drug.
Learn more
- Food Interactions
- Not Available
Products
Categories
- Drug Categories
- Classification
- Not classified
Chemical Identifiers
- UNII
- 71ANL51TLA
- CAS number
- 84-81-1
- InChI Key
- PFRQBZFETXBLTP-RCIYGOBDSA-N
- InChI
- InChI=1S/C41H56O2/c1-30(2)16-11-17-31(3)18-12-19-32(4)20-13-21-33(5)22-14-23-34(6)24-15-25-35(7)28-29-37-36(8)40(42)38-26-9-10-27-39(38)41(37)43/h9-10,16,18,20,22,24,26-28H,11-15,17,19,21,23,25,29H2,1-8H3/b31-18+,32-20+,33-22+,34-24+,35-28+
- IUPAC Name
- 2-[(2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl]-3-methyl-1,4-dihydronaphthalene-1,4-dione
- SMILES
- CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC1=C(C)C(=O)C2=C(C=CC=C2)C1=O
References
- General References
- Not Available
- External Links
- ChemSpider
- 4446660
- 42781
- ZINC
- ZINC000072131515
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Treatment Calcifications, Vascular 1 4 Completed Treatment Osteoporosis 1 4 Unknown Status Prevention Coronary Artery Calcifications / Kidney Diseases 1 2 Active Not Recruiting Treatment Calcifications, Vascular / Complication of Hemodialysis / Deficiency of Vitamin K2 / Systemic and Arterial Stiffness 1 2 Unknown Status Treatment Atherosclerosis / Carotid Disease 1 2, 3 Active Not Recruiting Treatment Postmenopausal Osteoporosis (PMO) 1 2, 3 Not Yet Recruiting Treatment End Stage Renal Disease on Dialysis 1 2, 3 Recruiting Prevention End Stage Renal Disease (ESRD) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.000266 mg/mL ALOGPS logP 9.01 ALOGPS logP 11.8 ChemAxon logS -6.3 ALOGPS pKa (Strongest Basic) -7.2 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 2 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 34.14 Å2 ChemAxon Rotatable Bond Count 17 ChemAxon Refractivity 193.11 m3·mol-1 ChemAxon Polarizability 74.54 Å3 ChemAxon Number of Rings 2 ChemAxon Bioavailability 0 ChemAxon Rule of Five No ChemAxon Ghose Filter No ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available GC-MS Spectrum - EI-B GC-MS splash10-003r-7891050000-fb45abd0445fd13b3287 Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Drug created on May 20, 2019 08:36 / Updated on June 12, 2020 10:53
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