Aspartate--tRNA(Asp) ligase

BE0001325ProteinThermus thermophilusaspS

Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp). It is acted on by 1 drug in DrugBank.

Gene name
aspS
UniProtKB entry
P36419Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
580 residues · 66,029 Da
Also known as
6.1.1.12 · Aspartyl-tRNA synthetase · AspRS · D-AspRS · Discriminating aspartyl-tRNA synthetase

Resolves to

Protein
UniProtP36419UniProt nameSYD_THETH
Gene
GenBank396501
Structure
PDB1EFWPDB1G51PDB1L0W
Drugs

What you can answer from here — as of September 04, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Aspartate--tRNA(Asp) ligase, and which indications are they being tested in?

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